V4390
VUF 8430二氢溴酸盐
≥97% (NMR)
别名:
2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester, S-(2-guanidylethyl)-isothiourea
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关于此项目
经验公式（希尔记法）:
C4H11N5S· 2HBr
化学文摘社编号:
分子量:
323.05
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
VUF 8430二氢溴酸盐, ≥97% (NMR)
InChI
1S/C4H11N5S.2BrH/c5-3(6)9-1-2-10-4(7)8;;/h1-2H2,(H3,7,8)(H4,5,6,9);2*1H
SMILES string
Br.Br.NC(=N)NCCSC(N)=N
InChI key
GPWJSTKHQMIXCA-UHFFFAOYSA-N
assay
≥97% (NMR)
form
solid
storage condition
desiccated
solubility
deionized water: 24 mg/mL
storage temp.
room temp
Quality Level
相关类别
Biochem/physiol Actions
VUF 8430 dihydrobromide is a potent histamine H4 receptor agonist, with a 33-fold selectivity over the histamine H3 receptor and negligible affinity for the other histamine receptor.
Features and Benefits
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Tamara E Galarza et al.
Biochemical pharmacology, 180, 114177-114177 (2020-07-30)
Epithelial-mesenchymal transition (EMT) contributes to cell invasion and metastasis during the progression of epithelial cancers. Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer growth, its function in the EMT is less known. In this
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