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Merck
CN

V4638

SAFC

L -缬氨酸

Pharma Manufacturing

别名:

(S)-α-缬氨酸, L-2-氨基-3-二甲基丁酸

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About This Item

线性分子式:
(CH3)2CHCH(NH2)CO2H
CAS号:
分子量:
117.15
Beilstein:
1721136
EC 号:
MDL编号:
UNSPSC代码:
12352209
NACRES:
NA.26

生物来源

non-animal source

质量水平

检测方案

≥98.5%

形式

powder

技术

cell culture | mammalian: suitable

杂质

endotoxin, heavy metals, trace metals, residual solvents, tested

mp

295-300 °C (subl.) (lit.)

溶解性

H2O: 25 mg/mL

适用性

suitable for manufacturing use

应用

pharmaceutical (small molecule)

异质活性

cytotoxicity, tested

储存温度

2-30°C

SMILES字符串

CC(C)[C@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1

InChI key

KZSNJWFQEVHDMF-BYPYZUCNSA-N

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我们用于生物制药加工的SAFC® 系列优质原料经过严格的质量控制流程,配合记录文件和技术专长帮助我们的客户达到M-Clarity Program规定的要求。

M-Clarity Program

我们全面的上游工艺化学品系列不仅为生物制药生产商提供生产传统和创新治疗药物所需的优质原料,而且帮助他们更快地将产品投放市场并简化监管问题。请相信我们能够为您带来透明的供应链和可靠的全球采购能力,以最佳的法规支持和服务简化您的产品认证。

应用

L-缬氨酸是一种支链必需氨基酸。它可以用作细胞培养基组分,用于治疗性重组蛋白和单克隆抗体的商业生物制造。

法律信息

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Shankar Sachidhanandam et al.
Nature neuroscience, 16(11), 1671-1677 (2013-10-08)
Neocortical activity can evoke sensory percepts, but the cellular mechanisms remain poorly understood. We trained mice to detect single brief whisker stimuli and report perceived stimuli by licking to obtain a reward. Pharmacological inactivation and optogenetic stimulation demonstrated a causal
Sonia Jego et al.
Nature neuroscience, 16(11), 1637-1643 (2013-09-24)
Rapid-eye movement (REM) sleep correlates with neuronal activity in the brainstem, basal forebrain and lateral hypothalamus. Lateral hypothalamus melanin-concentrating hormone (MCH)-expressing neurons are active during sleep, but their effects on REM sleep remain unclear. Using optogenetic tools in newly generated
Ihab Daou et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(47), 18631-18640 (2013-11-22)
We report a novel model in which remote activation of peripheral nociceptive pathways in transgenic mice is achieved optogenetically, without any external noxious stimulus or injury. Taking advantage of a binary genetic approach, we selectively targeted Nav1.8(+) sensory neurons for
Felix Stickel et al.
Archives of internal medicine, 165(16), 1835-1840 (2005-09-15)
Oxidative stress plays an important pathogenic role in hereditary hemochromatosis (HHC) and chronic hepatitis C virus infection (CHC). Several enzymes involved in the degradation of reactive oxidants and xenobiotics, such as glutathione S-transferase P1 (GSTP1) and manganese superoxide dismutase (MnSOD)
T De Smedt et al.
Toxicology letters, 231(3), 344-351 (2014-09-17)
On Saturday May 4, 2013, a train transporting chemicals derailed in the village of Wetteren (Belgium) and caused a leak of acrylonitrile (ACN). To assess the human exposure to acrylonitrile in the local population with the highest suspected exposure. Between

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