V4765
Valnoctamide
≥98% (NMR)
别名:
2-ethyl-3-methyl-pentanamide, Axiquel, Nirvanil
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关于此项目
经验公式（希尔记法）:
C8H17NO
化学文摘社编号:
分子量:
143.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
Valnoctamide, ≥98% (NMR)
InChI key
QRCJOCOSPZMDJY-UHFFFAOYSA-N
SMILES string
CCC(C)C(CC)C(N)=O
InChI
1S/C8H17NO/c1-4-6(3)7(5-2)8(9)10/h6-7H,4-5H2,1-3H3,(H2,9,10)
assay
≥98% (NMR)
form
powder
storage condition
desiccated
color
white to off-white
solubility
DMSO: 20 mg/mL, clear
storage temp.
room temp
Quality Level
Application
Valnoctamide has been used:
- as a mood stabilizer to study its anti-cytomegalovirus (anti-CMV) effects in newborn mice brain
- as a hypnotic sedative to study its cytotoxic effects on oligodendrocyte precursor cells (OPCs) and human oligodendroglioma cell line (HOG)
- as a mood stabilizer to study its effects on inhibition of human cytomegalovirus
Biochem/physiol Actions
Valnoctamide exhibits anti-cytomegalovirus (anti-CMV) properties. It has therapeutic effects against status epilepticus (SE) and neuropathic pain. Valnoctamide also shows therapeutic effects against bipolar disorders.
Valproic acid (VPA) and derivatives such as valpromide and valnoctamide are anti-convulsant, mood stabilizing drugs, believed to function as indirect GABA agonists by inhibiting the transamination of GABA.
Features and Benefits
This compound is featured on the Glutamate/GABA Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
H Steve White et al.
Epilepsia, 53(1), 134-146 (2011-12-14)
sec-Butyl-propylacetamide (SPD) is a one-carbon homolog of valnoctamide (VCD), a central nervous system (CNS)-active amide derivative of valproic acid (VPA) currently in phase II clinical trials. The study reported herein evaluated the anticonvulsant activity of SPD in a battery of
Rapid gas chromatographic assay for monitoring valnoctamide in plasma.
M Bialer et al.
Journal of chromatography, 337(2), 408-411 (1985-02-08)
A Haj-Yehia et al.
Journal of pharmaceutical sciences, 77(10), 831-834 (1988-10-01)
Valnoctamide (2-ethyl-3-methylpentanamide; VCD), an isomer of valpromide possessing both anxiolytic and antiepileptic properties, has been used as a tranquilizer in the treatment of anxiety and tension. As VCD is an isomer of valpromide (VPD), which is used both as an
M Radatz et al.
Epilepsy research, 30(1), 41-48 (1998-04-29)
The teratogenic properties of valproic acid (VPA) and its analogues depend to a great extent on their chemical structure. We investigated the structure-teratogenicity relationships of VPA, its structural isomer, valnoctic acid (VCA), and their two amide analogues, valpromide (VPD) and
Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus
Shekh A T, et al.
Epilepsia, 54(29), 99-102 (2013)
商品
Glutamine's role in neurotransmitter synthesis and transport highlights its importance in neuronal function and glutamate production.
谷氨酰胺是谷氨酸和GABA生物合成的常用前体。谷氨酰胺可以利用不同的谷氨酰胺载体在神经元和星形胶质细胞进行细胞内外转运。神经递质谷氨酸可以通过磷酸盐活化的谷氨酰胺酶的作用从谷氨酰胺合成。
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