V5015
VU0152100
≥98% (HPLC)
别名:
3-Amino-N-[(4-methoxyphenyl)methyl]-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxamide
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关于此项目
经验公式（希尔记法）:
C18H19N3O2S
化学文摘社编号:
分子量:
341.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >50 mg/mL
storage temp.
2-8°C
SMILES string
COc1ccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)cc1
InChI
1S/C18H19N3O2S/c1-10-8-11(2)21-18-14(10)15(19)16(24-18)17(22)20-9-12-4-6-13(23-3)7-5-12/h4-8H,9,19H2,1-3H3,(H,20,22)
InChI key
MDNWGCQSCGNTKH-UHFFFAOYSA-N
Biochem/physiol Actions
Positive allosteric modulator of muscarinic choline receptor M4.
Positive allosteric modulator of muscarinic choline receptor M4. Potentiates activation by acetylcholine, but posesses no intrinsic agonist activity alone.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.
DISCOVER Bioactive Small Molecules for Neuroscience
Paulina Cieślik et al.
Behavioural brain research, 359, 671-685 (2018-09-30)
Recent preclinical studies point to muscarinic and GABAB receptors as novel therapeutic targets for the treatment of schizophrenia. This study was aimed to assess the role of muscarinic and GABAB receptor interactions in animal models of schizophrenia, using positive allosteric
Bing Xue et al.
European journal of pharmacology, 820, 45-52 (2017-12-16)
Two key transmitters in the medial prefrontal cortex (mPFC), dopamine and acetylcholine, are believed to interact with each other to modulate local glutamatergic transmission, although molecular mechanisms underlying their crosstalk are poorly understood. Here we investigated effects of pharmacological manipulations
Kristine B Jørgensen et al.
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 202(1), 7-15 (2015-11-02)
The present study investigated the cholinergic system in the African naked mole-rat (Heterocephalus glaber) with focus on the muscarinic acetylcholine receptor subtypes M1 and M4. The protein sequences for the subtypes m 1-5 of the naked mole-rat were compared to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| V5015-25MG | 04061837481079 |
| V5015-5MG | 04061832078243 |