产品名称
抗-维生素B12单克隆抗体 小鼠抗, clone CD-29, ascites fluid
Quality Level
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
CD-29, monoclonal
contains
15 mM sodium azide
technique(s)
indirect ELISA: 1:5,000
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Application
单克隆抗维生素（B12）抗体已被用于酶联免疫吸附测定（ELISA）。
小鼠抗维生素B12单克隆抗体还可用于免疫细胞化学。
Biochem/physiol Actions
维生素B12可作为蛋氨酸合酶和L-甲基丙二酰−辅酶A突变酶的辅因子。它对于中枢神经系统（CNS）的维护和发育至关重要。维生素B12缺乏会导致巨幼细胞性贫血和神经病变。
维生素B12和叶酸可用于治疗中枢神经系统（CNS）发育、情绪和认知衰退疾病，包括某些痴呆症。
维生素B12调节基因组稳定性。尽管维生素B12 水平升高与肝脏和血液疾病有关；钴胺素缺乏症却与直立性低血压和抑郁症有关。该抗体还可检测辅酶B12和甲基维生素B12，但不与BSA、叶酸和5-甲基四氢叶酸缔合。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
General description
单克隆抗维生素B12抗体与人血浆和血清中的维生素B12以及维生素B12-KLH和维生素B12-BSA偶联物反应。
维生素B12或称钴胺素是一种水溶性维生素。它是所有维生素中最大、最复杂的维生素。维生素B12天然存在于动物食品、肉、奶、蛋、鱼和贝类中。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Christine M Pfeiffer et al.
The Journal of nutrition, 143(6), 957S-965S (2013-04-12)
Biochemical indicators of water-soluble vitamin (WSV) status were measured in a nationally representative sample of the U.S. population in NHANES 2003-2006. To examine whether demographic differentials in nutritional status were related to and confounded by certain variables, we assessed the
Henrik Birn et al.
American journal of physiology. Renal physiology, 282(3), F408-F416 (2002-02-08)
Megalin has previously been shown to bind and mediate endocytosis of transcobalamin (TC)-B(12). However, the physiological significance of this has not been established, and other TC-B(12) binding proteins have been suggested to mediate renal uptake of this vitamin complex. The
Fumio Watanabe
Experimental biology and medicine (Maywood, N.J.), 232(10), 1266-1274 (2007-10-26)
The usual dietary sources of vitamin B(12) are animal foods, meat, milk, egg, fish, and shellfish. As the intrinsic factor-mediated intestinal absorption system is estimated to be saturated at about 1.5-2.0 microg per meal under physiologic conditions, vitamin B(12) bioavailability
M Fenech
Mutation research, 475(1-2), 57-67 (2001-04-11)
Folic acid plays a critical role in the prevention of chromosome breakage and hypomethylation of DNA. This activity is compromised when Vitamin B12 (B12) concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM)
A A M Ermens et al.
Clinical biochemistry, 36(8), 585-590 (2003-11-26)
Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Not surprisingly, a
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