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W0519

WS-12

Name: WS-12
Brand: SIGMA

≥98% (HPLC), TRPM8 agonist, powder

别名:

(1R,2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboxamide

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关于此项目

经验公式（希尔记法）:

C₁₈H₂₇NO₂

化学文摘社编号:

68489-09-8

分子量:

289.41

UNSPSC Code:

12352200

PubChem Substance ID:

329830423

NACRES:

NA.25

MDL number:

MFCD11100191

Form:

powder

Assay:

≥98% (HPLC)

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属性

产品名称

WS-12, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(NC(=O)C2C[C@H](C)CC[C@H]2C(C)C)cc1

InChI

1S/C18H27NO2/c1-12(2)16-10-5-13(3)11-17(16)18(20)19-14-6-8-15(21-4)9-7-14/h6-9,12-13,16-17H,5,10-11H2,1-4H3,(H,19,20)/t13-,16?,17?/m1/s1

InChI key

HNSGVPAAXJJOPQ-NVPAJSRCSA-N

说明

Biochem/physiol Actions

WS-12 is a menthol derivative, that shows a specific binding affinity towards TRPM8 (transient receptor potential cation channel subfamily M member 8) receptor. TRPM8 is associated with prostate cancer and thus, WS-12 might be useful in reducing the progression of cancer.

WS-12 is a high-affinity, selective TRPM8 (cold menthol receptor 1; CMR1) agonist.

WS-12 is a high-affinity, selective TRPM8 (cold menthol receptor 1; CMR1) agonist. TRPM8 agonists induce a cooling sensation in sensory neurons and produce profound, mechanistically novel analgesia in chronic pain states such as neuropathic pain.

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

flash_point_f

No data available

flash_point_c

No data available

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000517448

0000457183

0000381006

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全球贸易项目编号

货号	GTIN
W0519-5MG	04061833237052