WH0003146M8
单克隆抗-HMGB1 小鼠抗
clone 2F6, purified immunoglobulin, buffered aqueous solution
别名:
抗-DKFZp686A04236, 抗-HMG1, 抗-HMG3, 抗-SBP1, 抗-高迁移率族蛋白b1
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关于此项目
Conjugate:
unconjugated
Clone:
2F6, monoclonal
Application:
ELISA (i), IF, IHC (p), WB
Citations:
12
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2F6, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable, western blot: 1-5 μg/mL
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... HMGB1(3146)
General description
高迁移率族蛋白1（HMGB1）是一种DNA结合蛋白，由C端带负电荷的氨基酸和两个称为BOX A和B的DNA结合基序组成。HMGB1定位于人染色体13q12.3。坏死细胞和神经炎表达HMGB1。激活后的单核细胞和巨噬细胞释放HMGB1。
Immunogen
HMGB1（NP_002119, 1 a.a.~ 90 a.a）带有GST标签的部分重组蛋白。仅GST标签的MW为26 KDa。
序列
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFK
序列
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFK
Application
在小鼠单克隆抗HMGB1抗体可用于使用荧光显微镜和蛋白质印迹检测胰腺导管腺癌（PDAC）细胞系中的HMGB1。
Biochem/physiol Actions
高迁移率族蛋白1（HMGB1）的功能是稳定核小体，并调节基因转录。HMGB1中核定位信号的磷酸化调节其在细胞质和细胞核之间的转运。它通过引发伴侣功能来帮助核小体重塑。炎症触发HMGB1的高表达，其抑制可用于治疗难治性肺炎支原体肺炎（RMPP）。HMGB1水平升高存在于心血管疾病中。HMGB1调节缺氧后再灌注后人肝细胞中的自噬。高HMGB1表达见于腺癌（AC）、胆囊癌和鳞状细胞/腺鳞癌（SC/ASC）。HMGB1的多态性存在于口腔鳞状细胞癌（OSCC）中。
Physical form
溶于pH7.4的磷酸盐缓冲盐水中的溶液
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
A functional variant at the miRNA binding site in HMGB1 gene is associated with risk of oral squamous cell carcinoma
Lin CY, et al.
Oncotarget, 8(21), 34630-34630 (2017)
Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell/adenosquamous carcinoma of gallbladder
Shi Z, et al.
American Journal of Translational Research, 7(10), 1532-1537 (2015)
Yam Nath Paudel et al.
Frontiers in pharmacology, 11, 613009-613009 (2021-03-19)
Epilepsy is a chronic brain disease afflicting around 70 million global population and is characterized by persisting predisposition to generate epileptic seizures. The precise understanding of the etiopathology of seizure generation is still elusive, however, brain inflammation is considered as
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| WH0003146M8-100UG | 04061832742632 |