WH0010841M1
Monoclonal Anti-FTCD antibody produced in mouse
clone 3A4, purified immunoglobulin, buffered aqueous solution
别名:
Anti-LCHC1, Anti-formiminotransferase cyclodeaminase
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关于此项目
Conjugate:
unconjugated
Clone:
3A4, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
indirect ELISA
indirect immunofluorescence
western blot
indirect ELISA
indirect immunofluorescence
western blot
Species reactivity:
human
Citations:
6
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
Uniprot accession no.:
产品名称
Monoclonal Anti-FTCD antibody produced in mouse, clone 3A4, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3A4, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1-5 μg/mL
isotype
IgG2aκ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... FTCD(10841)
Application
Monoclonal Anti-FTCD antibody produced in mouse has been used in indirect immunofluorescence staining, immunohistochemistry and immunocytochemistry.
Biochem/physiol Actions
Formimidoyltransferase cyclodeaminase (FTCD) deficiency is associated with formiminoglutamic aciduria. FTCD is considered as a therapeutic target for hepatocellular carcinoma (HCC). Mutations in FTCD is linked to glutamate formiminotransferase deficiency.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
FTCD is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool.(supplied by OMIM) Formimidoyltransferase cyclodeaminase (FTCD) gene is localized in human fetal and adult liver. The gene is located on human chromosome 21q22.3.
Immunogen
FTCD (NP_996848, 440 a.a. ~ 541 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDLQVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQE
Sequence
LQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDLQVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQE
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Differential intracellular trafficking of von Willebrand factor (vWF) and vWF propeptide in porcine endothelial cells lacking Weibel-Palade bodies and in human endothelial cells
Royo T and Mart
Atherosclerosis, 167(1), 55-63 (2003)
Using a yeast two-hybrid system to identify FTCD as a new regulator for HIF-1alpha in HepG2 cells
Yu Z, et al.
Cellular Signalling, 26(7), 1560-1566 (2014)
Cloning and characterization of human FTCD on 21q22. 3, a candidate gene for glutamate formiminotransferase deficiency
Solans A, et al.
Cytogenetic and genome research, 88(1-2), 43-49 (2000)
Allelic spectrum of formiminotransferase-cyclodeaminase gene variants in individuals with formiminoglutamic aciduria
Majumdar R, et al.
Molecular Genetics & Genomic Medicine, 5(6), 795-799 (2017)
Alteration of poly (ADP-ribose) glycohydrolase nucleocytoplasmic shuttling characteristics upon cleavage by apoptotic proteases
Bonicalzi M, et al,
Biology of the Cell, 95(9), 635-644 (2003)
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