WH0283455M1
Monoclonal Anti-KSR2 antibody produced in mouse
clone 6F12, purified immunoglobulin, buffered aqueous solution
别名:
Anti-FLJ25965, Anti-kinase suppressor of ras 2
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
6F12, monoclonal
表单
buffered aqueous solution
种属反应性
human
技术
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型
IgG2aκ
GenBank登记号
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... KSR2(283455)
一般描述
Kinase suppressor of ras 2 (KSR2) is a scaffolding protein.
免疫原
KSR2 (NP_775869, 411 a.a. ~ 500 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
PAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEV
Sequence
PAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEV
生化/生理作用
Kinase suppressor of ras 2 (KSR2) has a role in the growth and proliferation of breast tumor cells. It takes part in signaling pathways and associates with calcineurin.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline, pH 7.4
法律信息
GenBank is a registered trademark of United States Department of Health and Human Services
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
Laura R Pearce et al.
Cell, 155(4), 765-777 (2013-11-12)
Kinase suppressor of Ras 2 (KSR2) is an intracellular scaffolding protein involved in multiple signaling pathways. Targeted deletion of Ksr2 leads to obesity in mice, suggesting a role in energy homeostasis. We explored the role of KSR2 in humans by
M Jia et al.
Experimental oncology, 32(3), 209-212 (2011-03-16)
To study the expression of Kinase Suppressor of Ras 2 (KSR2) in human breast tumors and its effect on proliferation of breast epithelial cells. We reported previously that KSR2 was up-regulated in immortalized human breast epithelial cells. Proteomics technologies, systems
The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE).
E Giurisato et al.
Molecular biology of the cell, 25(11), 1769-1781 (2014-03-29)
Store-operated calcium entry (SOCE) is the predominant Ca(2+) entry mechanism in nonexcitable cells and controls a variety of physiological and pathological processes. Although significant progress has been made in identifying the components required for SOCE, the molecular mechanisms underlying it
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