Anti-phospho-YAP1 (pTyr³⁵⁷) antibody, Mouse monoclonal

Monoclonal Anti-phospho-YAP1 (pTyr357) (mouse IgM isotype) is derived from the hybridoma PYP-76 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic phosphopeptide corresponding to a fragment containing (pTyr357) of human YAP1 conjugated to KLH. Yes-associated protein 1 (YAP1) is a modular adapter protein with multiple protein interaction domains that was originally identified based on its interaction with the Src-family tyrosine kinase c-Yes. YAP1 contains a proline-rich amino terminus, a WW domain, a coiled-coil and a PDZ-binding motif at the extreme C-terminus.

Anti-phospho-YAP1 (pTyr357) antibody, Mouse monoclonal has been used in

• immunoblotting
• enzyme linked immunosorbent assay (ELISA)
• immunofluorescence

YAP1 has been shown to stabilize p73 by preventing Itch-mediated ubiquitination of p73.

YAP1 is a WW domain containing protein that is known to associate with a wide range of transcription factors and functions as a transcriptional co-activator. It may also regulate p73 gene function in response to DNA damage. Alterations in YAP1 have been associated with tumor development

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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