SMILES string
N1(CCCCC1)N=O
InChI
1S/C5H10N2O/c8-6-7-4-2-1-3-5-7/h1-5H2
InChI key
UWSDONTXWQOZFN-UHFFFAOYSA-N
grade
certified reference material, TraceCERT®
product line
TraceCERT®
CofA
current certificate can be downloaded
packaging
ampule of 1 mL
manufacturer/tradename
Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
concentration
5000 μg/mL in methanol
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
environmental
format
single component solution
storage temp.
2-8°C
Quality Level
General description
Nitrosamines are chemical compounds that can form during drug manufacturing and may pose health risks, including carcinogenicity.
1-Nitrosopiperidine solution is commonly employed as a certified reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices
1-Nitrosopiperidine solution is commonly employed as a certified reference compound in analytical chemistry. It is utilized in chromatographic and spectrometric techniques for the detection and quantification of nitrosamines in chemical, pharmaceutical, and environmental matrices
Application
1-Nitrosopiperidine solution may be used as an analytical reference standard for the determination of nitrosamine impurities in pharmaceutical preparations using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Analysis Note
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Legal Information
TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
51.8 °F - closed cup
flash_point_c
11 °C - closed cup
法规信息
危险化学品
此项目有
Kinetics of the oxidation of N-aminopiperidine with chloramine
Darwich.Ch, et al.
Kinetics and Catalysis, 50, 103-110 (2009)
Simultaneous analysis of carcinogenic N-nitrosamine impurities in metformin tablets using on-line in-tube solid-phase microextraction coupled with liquid chromatography-tandem mass spectrometry
Ishizaki A, et al.
Journal of Chromatography A, 1710, 464416-464416 (2023)
Kinetics of the oxidation of N-aminopiperidine with chloramine
Darwich.Ch, et al.
Kinetics and Catalysis, 50(1), 103-110 (2009)
Hansen L Wong et al.
Chemical research in toxicology, 16(10), 1298-1305 (2003-10-21)
N-Nitrosopiperidine (NPIP) is a potent rat nasal carcinogen whereas N-nitrosopyrrolidine (NPYR), a hepatic carcinogen, is weakly carcinogenic in the nose. NPIP and NPYR may be causative agents in human cancer. P450-catalyzed alpha-hydroxylation is the key activation pathway by which these
Samuel González-Mancebo et al.
Mutation research, 558(1-2), 45-51 (2004-03-24)
The genotoxicity of nitrosopiperidine and six alkyl derivatives was studied by use of the Ames tester strains TA100 and TA1535 in the pre-incubation method. Among the compounds investigated, those exhibiting genotoxic activity under the experimental conditions employed were only genotoxic
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