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经验公式（希尔记法）:
C18H34ClN2O8PS
化学文摘社编号:
分子量:
504.96
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
产品名称
克林霉素磷酸酯, United States Pharmacopeia (USP) Reference Standard
InChI key
UFUVLHLTWXBHGZ-MWBQRTRKSA-N
SMILES string
CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O
InChI
1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1
grade
pharmaceutical primary standard
API family
clindamycin
manufacturer/tradename
USP
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
−20°C
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Analysis Note
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
Application
Clindamycin phosphate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Clindamycin Phosphate Gel
- Clindamycin Phosphate Vaginal Cream
- Clindamycin Phosphate Topical Suspension
- Clindamycin Phosphate Vaginal Inserts
- Clindamycin Phosphate Topical Solution
- Clindamycin Injection
Biochem/physiol Actions
Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
General description
Clindamycin is a lincosamide antibiotic which is considered as a semisynthetic derivative of lincomycin. It is mainly used as an antimicrobial agent.
Other Notes
Antibacterial and antiprotozoal antibiotic of the licosamide class.
Sales restrictions may apply.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
D W Scott et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 39(12), 753-756 (1998-12-23)
Clindamycin hydrochloride capsules (11 mg/kg body weight, q24 h) were administered orally to 20 dogs with deep staphylococcal pyoderma. Response to therapy was excellent in 100% of the dogs. Duration of therapy varied from 21 to 91 d, with an
James Q Del Rosso et al.
Cutis, 81(5), 405-408 (2008-06-12)
An aqueous gel formulation containing solubilized clindamycin phosphate 1.2% and a stable combination of both solubilized and crystalline tretinoin 0.025% (clin/tret) has been evaluated in 3 pivotal phase 3 studies, among other studies including a 52-week trial. The pivotal studies
Fulminant pseudomembranous colitis caused by clindamycin phosphate vaginal cream.
M F Trexler et al.
The American journal of gastroenterology, 92(11), 2112-2113 (1997-11-15)
Vuk Uskoković et al.
Journal of pharmaceutical sciences, 103(2), 567-579 (2014-01-03)
Nanoparticulate composites of hydroxyapatite (HAp) and chitosan were synthesized by ultrasound-assisted sequential precipitation and characterized for their microstructure at the atomic scale, surface charge, drug release properties, and combined antibacterial and osteogenic response. Crystallinity of HAp nanoparticles was reduced because
Le Ngoc Tran et al.
Journal of chromatography. A, 1356, 289-293 (2014-07-20)
An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clindamycin phosphate (CLIP) as a chiral selector. A sol solution consisting of 6 × 10(-3)M of polyethylene glycol
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