NanoFabTx™ Drug Delivery Selection Guide
Introduction
Selecting the right formulation tools and delivery platforms is a key step in the advancement of pharmaceutical research and development. With the increasing complexity of therapeutic modalities and delivery challenges, researchers require dependable, streamlined solutions to optimize their workflows and accelerate progress from discovery to clinical evaluation. Our offerings include a broad range of advanced formulation tools and user-friendly screening kits, empowering scientists to enhance efficiency, ensure reproducibility, and enable scalable solutions throughout their research and development processes.
Potential applications of our NanoFabTx™ platform include:
- Delivery of small molecules and nucleic acids
- Screening and selection of optimal formulations for liposomes, nanoparticles, and microparticles
- Optimal particle size control and determination
- Drug-loading capacity and efficiency optimization
This guide is designed to help you make informed decisions for your drug delivery requirements by providing an overview of essential technologies and ready-to-use product options that support your innovative research objectives.
Formulation Devices
Figure 1.NanoFabTx™ NanoFlash CIJ (confined impingement jet) device.
Figure 2.NanoFabTX™-DOTAP Lipid Mix, a ready-to-use nanoformulation blend for the synthesis of cationic DOTAP-functionalized liposomes using extrusion or microfluidic methods (protocols and reagents included).
NanoFabTx™ drug delivery kits (Figure 2) provide researchers with a streamlined, ready‑to‑use platform for developing lipid‑ and polymer‑based delivery systems with high reproducibility and minimal optimization burden. Each kit includes pre‑formulated lipid mixes or polymer screening components engineered to support efficient encapsulation, targeted delivery, and controlled release of a range of payloads, including nucleic acids, small molecules, and proteins. By offering standardized blends such as DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane), DC‑Chol (3β-[N-(N',N'-dimethylaminoethane)-carbamoyl]cholesterol), PEG‑lipids, functionalized targeting lipids (folate, mannose, RGD), and reactive chemistries (azide, maleimide, DBCO), these kits enable rapid formulation prototyping across diverse therapeutic applications—from mRNA and siRNA delivery to insoluble drug solubilization and antibody‑conjugated nanoparticles. Integrated protocols tailored for microfluidic devices (e.g., NanoFabTx™ NanoFlash CIJ and microfluidic mixers) further ensure consistent particle size control and batch‑to‑batch uniformity. Together, these comprehensive kits reduce formulation complexity, accelerate screening workflows, and empower researchers to quickly identify optimal delivery systems for parenteral administration and sustained or self‑dissociating release profiles.
Table 2. NanoFabTx™ Drug Delivery Kits – Self Dissociation Release Profiles
Table 3. NanoFabTx™ Drug Delivery Kits – Sustainable Release Profiles
Figure 3.NanoFabTx™ Polymers for Microneedles: hyaluronic acid sodium salt.
Microneedles are tiny polymeric projections that come in various lengths, pitches, and arrays, designed to deliver topical therapeutic molecules and vaccine antigens through the skin. Made from biodegradable synthetic or natural polymers, they can be efficiently formulated with NanoFabTx™ Polymers for Microneedles (Figure 3) using microneedle templates.
Offering versatile options for dissolving and hydrogel-based arrays, NanoFabTx™ polymers are chosen for their biocompatibility and ease of processing, allowing researchers to create microneedle patches that enable controlled delivery and patient-friendly administration.
Figure 4.Microneedle template, which is 10x10 array, height 600 μm, base size 200 μm, 500 µm pitch.
Microneedle templates (Figure 4) provide precise dimensions and array configurations for creating consistent and reliable microneedle structures. These templates are designed to support accurate fabrication, ensuring uniform needle height, pitch, and shape for controlled delivery applications.
Microneedle Applicator
Note: accessory for microneedle templates; not needed for formulation
Microneedle applicator accessories (Figure 5) are designed to simplify the handling and application of microneedle templates. These tools ensure consistent placement and ease of use, supporting accurate and reproducible microneedle delivery in research and development workflows.
Figure 5.Microneedle spring applicator set showing (a) the spring applicator, (b) the loader’s cap, (c) the loader, (d) the button, and (e) the microneedles.
NanoFabTx™ formulation devices (Figure 1) are designed to simplify particle and lipid system preparation. With advanced options for microfluidic mixing and flash precipitation, these tools enable rapid, precise, and scalable control over parameters such as particle size, uniformity, encapsulation efficiency, and reproducibility.
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