Merck
CN

ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

别名:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
物种:
UniProtKB ID:
基因ID:
  • Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
  • dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Thale Cress(818265) ABC transporter B family member 1
  • naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
  • cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1

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Small Molecule - Agonist

货号
说明
物种
9(10H)-吖啶酮, 99%,
物种
human

Small Molecule - Antagonist

货号
说明
物种
氯磺酰异氰酸酯, 98%,
物种
human
奥美拉唑, solid,
物种
human
克霉唑, ,
物种
mouse, human
红霉素, BioReagent, suitable for cell culture,
物种
mouse, human
红霉素, potency: ≥850 μg per mg,
物种
mouse, human

Antibodies

货号
说明
物种反应性
应用
Anti-P-Glycoprotein Mouse mAb (C219), liquid, clone C219, Calbiochem®,
物种反应性
hamster, human, mouse, rat
应用
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
物种反应性
hamster, human
应用
flow cytometry
immunocytochemistry

immunohistochemistry

western blot
Anti-MDR1 Antibody, conformational extracellular epitope, clone UIC2, clone UIC2, Chemicon®, from mouse,
物种反应性
human, primate
应用
flow cytometry
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)
Anti-MDR1 Antibody, clone UIC2, azide free, clone UIC2, Chemicon®, from mouse,
物种反应性
human, primate
应用
flow cytometry
immunofluorescence

immunohistochemistry

immunoprecipitation (IP)
Anti-ABCB1 antibody produced in rabbit FITC conjugated, affinity isolated antibody,
物种反应性
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep, zebrafish
应用
immunohistochemistry

Cell Lines

货号
说明
物种
SB-MDR1-HEK293, recombinant, expressed in HEK 293 cells,
物种
human
肾脏PTEC MDR1敲除细胞[MDR1敲除(-/-)], ,
物种
human
MDR1 Knockout HepaRG Cells, 1 vial,
物种
human
MDR1 Knockout Caco-2 Cells, one vial,
物种
human
CAR Knockout HepaRG Cells, 1 vial,
物种

Kits

货号
说明
物种
多药耐药分析试剂盒, (Fluorometric MDR Assay),
物种
human, mouse, rat

Small Molecule - Mixed Agonist/Antagonist

货号
说明
物种
地塞米松, powder, BioReagent, suitable for cell culture, ≥97%,
物种
mouse, rat, human
氟哌啶醇, powder,
物种
human, rat

Proteins

货号
说明
物种
SB-MDR1-Hi5-PREDEASY-ATP酶检测试剂盒, membrane based kit for Human MDR1 ATPase Transport Assays,
物种
human
PrEST Antigen ABCB1, Prestige Antibodies® Powered by Atlas Antibodies, buffered aqueous solution,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human ABCB1,
物种
human