Merck
CN

ACHE

acetylcholinesterase

别名:
ACEE, ARACHE, N-ACHE, YT
物种:
UniProtKB ID:
基因ID:
  • Human(43) Summary: Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. [provided by RefSeq, Jul 2008]
  • Mouse(11423) acetylcholinesterase
  • Rat(83817) acetylcholinesterase
  • domestic guinea pig(100422792) acetylcholinesterase
  • sheep(101123006) acetylcholinesterase
  • cow(540446) acetylcholinesterase
  • domestic cat(493674) acetylcholinesterase
  • Zebrafish(114549) acetylcholinesterase
  • chicken(396388) acetylcholinesterase
  • naked mole-rat(101705724) acetylcholinesterase
  • dog(489828) acetylcholinesterase

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Small Molecule - Activator

货号
说明
物种
2-吡啶醛肟甲氯, ,
物种
human
氯解磷定, United States Pharmacopeia (USP) Reference Standard,
物种
human

Small Molecule - Agonist

货号
说明
物种
氯化乙酰硫代胆碱, ≥99% (TLC), powder,
物种
human

Antibodies

货号
说明
物种反应性
应用
Anti-Acetylcholinesterase (AChE) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物种反应性
human
应用
immunofluorescence
western blot
Anti-Acetylcholinesterase Antibody, clone AE-1, clone AE-1, Chemicon®, from mouse,
物种反应性
bovine, canine, chicken, guinea pig, human, monkey
应用
ELISA
immunohistochemistry

immunoprecipitation (IP)
Anti-ACHE antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物种反应性
cat, human, mouse, rabbit, rat
应用
ELISA
flow cytometry

immunofluorescence

western blot
Anti-ACHE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
Anti-ACHE antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, rat
应用
western blot

Small Molecule - Inhibitor

货号
说明
物种
东莨菪内酯, ≥99%,
物种
human
1,5-双(4-烯丙基二甲基氨苯基)戊-3-酮二溴, ,
物种
human
新斯的明, ≥98% (HPLC and titration), powder,
物种
human
吡啶-2-乙醛肟甲碘化物, 99%,
物种
human
新斯的明, European Pharmacopoeia (EP) Reference Standard,
物种
human

Kits

货号
说明
物种
乙酰胆碱酯酶活性检测试剂盒, sufficient for 100 colorimetric tests,
物种
mouse, human

Proteins

货号
说明
物种
乙酰胆碱酯酶 来源于人类红细胞, buffered aqueous solution, ≥500 units/mg protein (BCA),
物种
human
乙酰胆碱酯酶 人, recombinant, expressed in HEK 293 cells, lyophilized powder, ≥1,000 units/mg protein (Lowry),
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human ACHE,
物种
human