Merck
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ADORA2A

adenosine A2a receptor

别名:
A2aR, ADORA2, RDC8
物种:
UniProtKB ID:
基因ID:
  • Human(135) Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
  • Mouse(11540) adenosine A2a receptor
  • Rat(25369) adenosine A2a receptor
  • chicken(427705) adenosine A2a receptor
  • naked mole-rat(101718082) adenosine A2a receptor
  • domestic guinea pig(100135473) adenosine A2a receptor
  • sheep(101112926) adenosine A2a receptor
  • cow(617828) adenosine A2a receptor
  • Horse(100034039) adenosine A2a receptor
  • domestic cat(101080742) adenosine A2a receptor
  • dog(403960) adenosine A2a receptor

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Small Molecule - Agonist

货号
说明
物种
CGS-21680 盐酸盐 水合物, solid,
物种
human
腺苷, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
腺苷, ,
物种
human
腺苷, United States Pharmacopeia (USP) Reference Standard,
物种
human
腺苷, European Pharmacopoeia (EP) Reference Standard,
物种
human

Small Molecule - Antagonist

货号
说明
物种
苏木精, certified by the Biological Stain Commission,
物种
rat
苏木精, ,
物种
rat
3-异丁基-1-甲基黄嘌呤, BioUltra, ≥99%,
物种
rat
3-甲基黄嘌呤, 98%,
物种
rat
9-甲基腺嘌呤, 97%,
物种
rat

Antibodies

货号
说明
物种反应性
应用
Anti-ADORA2A antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
flow cytometry
western blot
Anti-A2A Adenosine Receptor antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
canine, human
应用
immunohistochemistry
immunoprecipitation (IP)

western blot
Anti-ADORA2A antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-ADORA2A antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
ELISA
immunofluorescence

immunohistochemistry
Anti-ADORA2A (C-terminal) antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, canine, guinea pig, horse, human, mouse, rabbit, rat
应用
immunohistochemistry
western blot

Small Molecule - Inhibitor

货号
说明
物种
EHNA 盐酸盐, ≥98% (HPLC),
物种
human
Dilazep dihydrochloride, powder,
物种
human
α-萘黄酮, ≥98%,
物种
human, rat
5′-脱氧-5′-腺苷, ,
物种
human, rat, mouse
高良姜黄素, autophagy inducing flavonoid,
物种
human, rat

Small Molecule - Ligand

货号
说明
物种
2-氯-2′-脱氧腺苷, antileukemic,
物种
rat, human
1,7-二甲基黄嘌呤, ~98%, solid,
物种
rat, human
Chloro-IB-MECA, solid, ≥98% (HPLC),
物种
human, rat
腺苷, ≥99%,
物种
human, rat

Small Molecule - Mixed Agonist/Antagonist

货号
说明
物种
2-氟肾上腺素-9-β-D-阿拉伯呋喃糖苷, DNA synthesis and methylation inhibitor,
物种
rat, human
2-氟腺苷, 97%,
物种
rat, human
2-碘腺苷, 97%,
物种
human, rat
2-氯腺苷, ,
物种
human, rat
Chloro-IB-MECA, solid, ≥98% (HPLC),
物种
human, rat

Proteins

货号
说明
物种
PrEST Antigen ADORA2A, Prestige Antigens Powered by Atlas Antibodies, buffered aqueous solution,
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Adora2a,
物种
mouse
MISSION® esiRNA, targeting human ADORA2A, SPECC1L-ADORA2A,
物种
human