CN
GRIA2
glutamate receptor, ionotropic, AMPA 2
别名:
GLUR2, GLURB, GluA2, GluR-K2, HBGR2
物种:
Human GRIA2 (2891), Mouse Gria2 (14800), Rat Gria2 (29627), chicken GRIA2 (414894), cow GRIA2 (614283), naked mole-rat Gria2 (101708417), domestic guinea pig Gria2 (100379153), sheep GRIA2 (443272), Horse GRIA2 (100069331), domestic cat GRIA2 (101088234)
UniProtKB ID:
基因ID:
- Human(2891) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
- Mouse(14800) glutamate receptor, ionotropic, AMPA2 (alpha 2)
- Rat(29627) glutamate receptor, ionotropic, AMPA 2
- chicken(414894) glutamate receptor, ionotropic, AMPA 2
- cow(614283) glutamate receptor, ionotropic, AMPA 2
- naked mole-rat(101708417) glutamate receptor, ionotropic, AMPA 2
- domestic guinea pig(100379153) glutamate receptor, ionotropic, AMPA2 (alpha 2)
- sheep(443272) glutamate receptor, ionotropic, AMPA 2
- Horse(100069331) glutamate receptor, ionotropic, AMPA 2
- domestic cat(101088234) glutamate receptor, ionotropic, AMPA 2
- dog(482667) glutamate receptor, ionotropic, AMPA 2
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Small Molecule - Agonist
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Small Molecule - Antagonist
Antibodies
货号
说明
物种反应性
应用
抗谷氨酸受体2 & 3抗体, Chemicon®, from rabbit,
物种反应性
gerbil, guinea pig, hamster, human, monkey, mouse, rat
应用
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
抗GluR2抗体, from rabbit, purified by affinity chromatography,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot
抗-GluR2/3抗体, Upstate®, from rabbit,
物种反应性
chicken, human, monkey, mouse, rat
应用
immunoprecipitation (IP)
western blot
western blot
Anti-GluR2 Antibody, clone 6C4, Alexa Fluor™ 488 Conjugate, clone 6C4, from mouse, ALEXA FLUOR™ 488,
物种反应性
mouse, rat
应用
immunocytochemistry
immunohistochemistry
immunohistochemistry
抗-GluR2抗体，克隆14C12.2, clone 14C12.2, from mouse,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Small Molecule - Blocker
货号
说明
物种
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
物种
human