Merck
CN

SCNN1A

sodium channel, non-voltage-gated 1 alpha subunit

别名:
BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1
物种:
UniProtKB ID:
基因ID:
  • Human(6337) Summary: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]
  • Mouse(20276) sodium channel, nonvoltage-gated 1 alpha
  • Rat(25122) sodium channel, nonvoltage-gated 1 alpha
  • cow(282348) sodium channel, non-voltage-gated 1 alpha subunit
  • dog(403650) sodium channel, non-voltage-gated 1 alpha subunit
  • domestic cat(101091122) sodium channel, non-voltage-gated 1 alpha subunit
  • chicken(396050) sodium channel, non-voltage-gated 1 alpha subunit
  • naked mole-rat(101700410) sodium channel, non-voltage-gated 1 alpha subunit
  • sheep(443488) sodium channel, non-voltage-gated 1 alpha subunit
  • domestic guinea pig(100135613) sodium channel, nonvoltage-gated 1 alpha

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Small Molecule - Antagonist

货号
说明
物种
拉莫三嗪, ≥98%, powder,
物种
rat, human
5-(N,N-二甲基)阿米洛利 盐酸盐, ,
物种
rat, mouse, human
卡马西平, meets USP testing specifications,
物种
rat, human

Antibodies

货号
说明
物种反应性
应用
Monoclonal Anti-ENaC alpha-FITC antibody produced in mouse, clone 2G4,
物种反应性
mouse, rat
应用
immunohistochemistry
western blot
Anti-SCNN1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
Monoclonal Anti-ENaC alpha antibody produced in mouse, clone 2G4,
物种反应性
mouse, rat
应用
immunohistochemistry
western blot
Monoclonal Anti-ENaC alpha-Biotin antibody produced in mouse, clone 2G4,
物种反应性
mouse, rat
应用
immunohistochemistry
western blot
Monoclonal Anti-ENaC alpha-FITC antibody produced in mouse, clone 14E10,
物种反应性
mouse, rat
应用
immunohistochemistry
western blot

Small Molecule - Blocker

货号
说明
物种
拉莫三嗪, ≥98%, powder,
物种
rat, human
卡马西平, meets USP testing specifications,
物种
rat, human

Small Molecule - Inhibitor

货号
说明
物种
苯扎咪 盐酸盐 水合物, ≥98% (HPLC),
物种
mouse, rat, human
5-(N-甲基-N-异丁基)阿米洛利, ≥98% (TLC), powder,
物种
mouse, rat, human
5-(N,N-二甲基)阿米洛利 盐酸盐, ,
物种
rat, mouse, human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Scnn1a,
物种
mouse
MISSION® esiRNA, targeting human SCNN1A,
物种
human