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P203

Phenamil methanesulfonate salt

Name: Phenamil methanesulfonate salt
Brand: SIGMA

PPARγ inducer, solid

别名:

3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt

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关于此项目

线性分子式:

C₁₂H₁₂ClN₇O · CH₃SO₃H

化学文摘社编号:

1161-94-0

分子量:

401.83

UNSPSC Code:

12352200

PubChem Substance ID:

24277869

NACRES:

NA.77

MDL number:

MFCD00274070

Form:

solid

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属性

产品名称

Phenamil methanesulfonate salt, solid

form

solid

Quality Segment

100

color

yellow

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.5 mg/mL, DMSO: ≥5 mg/mL (with warming), 0.1 M HCl: insoluble, H₂O: insoluble

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.Nc1nc(N)c(nc1Cl)C(=O)NC(=N)Nc2ccccc2

InChI

1S/C12H12ClN7O.CH4O3S/c13-8-10(15)19-9(14)7(18-8)11(21)20-12(16)17-6-4-2-1-3-5-6;1-5(2,3)4/h1-5H,(H4,14,15,19)(H3,16,17,20,21);1H3,(H,2,3,4)

InChI key

MHPIZTURFVSLTJ-UHFFFAOYSA-N

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

说明

General description

Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).

Application

Phenamil methanesulfonate salt has been used:

to stimulate adipocyte differentiation in 3T3 cells
to test its effect on lateral flagella expression in Vibrio shilonii
in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation

Biochem/physiol Actions

Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000187313

0000159859

0000159860