NR3C2

nuclear receptor subfamily 3, group C, member 2

Synonyms:

MCR, MLR, MR, NR3C2VIT

Species:

UniProtKB ID:

Gene ID:

Human(4306) Summary: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Mouse(110784) nuclear receptor subfamily 3, group C, member 2
Rat(25672) nuclear receptor subfamily 3, group C, member 2
sheep(101107046) nuclear receptor subfamily 3, group C, member 2
cow(280861) nuclear receptor subfamily 3, group C, member 2
cow(537614) nuclear receptor subfamily 3, group C, member 2
domestic cat(101081977) nuclear receptor subfamily 3, group C, member 2
Horse(100062570) nuclear receptor subfamily 3, group C, member 2
dog(475461) nuclear receptor subfamily 3, group C, member 2
chicken(374131) nuclear receptor subfamily 3, group C, member 2
domestic guinea pig(100735309) nuclear receptor subfamily 3, group C, member 2
Zebrafish(562171) nuclear receptor subfamily 3, group C, member 2

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