Merck
CN

SNCA

synuclein, alpha (non A4 component of amyloid precursor)

别名:
NACP, PARK1, PARK4, PD1
物种:
Human SNCA (6622), Mouse Snca (20617), Rat Snca (29219), cow SNCA (282857), naked mole-rat Snca (101700039), domestic cat SNCA (101091694), chicken SNCA (395393), sheep SNCA (100294604), dog SNCA (478478), Horse SNCA (100053270)
UniProtKB ID:
P37840, A8K2A4, Q13701, Q4JHI3, Q6IAU6
基因ID:
  • Human(6622) Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
  • Mouse(20617) synuclein, alpha
  • Rat(29219) synuclein, alpha (non A4 component of amyloid precursor)
  • cow(282857) synuclein, alpha (non A4 component of amyloid precursor)
  • naked mole-rat(101700039) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic cat(101091694) synuclein, alpha (non A4 component of amyloid precursor)
  • chicken(395393) synuclein, alpha (non A4 component of amyloid precursor)
  • sheep(100294604) synuclein, alpha (non A4 component of amyloid precursor)
  • dog(478478) synuclein, alpha (non A4 component of amyloid precursor)
  • Horse(100053270) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic guinea pig(100725375) synuclein, alpha (non A4 component of amyloid precursor)

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Antibodies

货号
说明
物种反应性
应用
MABN389
抗-聚集α-突触核蛋白抗体，克隆5G4, clone 5G4, from mouse, purified by affinity chromatography,
物种反应性
human
应用
ELISA
immunohistochemistry
western blot
MABN826
抗-磷酸-α-突触核蛋白（Ser129）抗体，克隆81A, clone 81A, from mouse,
物种反应性
human, mouse
应用
electron microscopy
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
S5566
抗 α-突触核蛋白抗体，小鼠单克隆, clone Syn211, purified from hybridoma cell culture,
物种反应性
human, zebra finch
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
AB5038
抗突触核蛋白α抗体, serum, Chemicon®,
物种反应性
human, rat
应用
immunocytochemistry
immunohistochemistry
western blot
AB5038P
Anti-Synuclein α Antibody, Chemicon®, from rabbit,
物种反应性
human, rat
应用
immunohistochemistry
western blot

Proteins

货号
说明
物种
S7820
α-突触核蛋白 人, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
物种
human
AG938
突触核蛋白，α，重组人, ,
物种
human
S1071
α-Synuclein A53T 人, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
物种
human
AG549
α-synuclein 61-140, human, ,
物种
human
S4447
α-Synuclein E46K 人, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
物种
human

esiRNA

货号
说明
物种
EHU140811
MISSION® esiRNA, targeting human SNCA (2),
物种
human
EHU095611
MISSION® esiRNA, targeting human SNCA (1),
物种
human