PRS4401
抗-ZBP1 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
抗-DAI, 抗-DLM-1, 抗Z-DNA结合蛋白1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
7
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 39-45 kDa
species reactivity
human, rat, mouse
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ZBP1(81030)
General description
Z-DNA结合蛋白1（ZBP1），又称干扰素（IFN）γ诱导基因，是一种胞质DNA传感器。它属于Z-DNA结合蛋白家族。ZBP1主要在小肠和淋巴组织中表达。该基因位于人染色体20q13.3上。
Immunogen
由人ZBP1羧基末端附近的18个氨基酸组成的肽。
Application
兔抗ZBP1抗体可用于蛋白印迹。
Biochem/physiol Actions
Z-DNA结合蛋白1（ZBP1）在DNA介导的先天免疫应答中起主要作用。它增强了活化B细胞（NFκB）的核因子K轻链增强子的活化和促炎细胞因子的产生。
Physical form
溶剂为含有0.02％叠氮化钠的磷酸盐缓冲盐水
Other Notes
可以使用阻断肽SBP4401阻断该抗体的作用。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
ZBP1: innate sensor regulating cell death and inflammation
Kuriakose T and Kanneganti TD
Trends in Immunology, 39(2), 123-134 (2018)
Functional roles of pattern recognition receptors that recognize virus nucleic acids in human adipose-derived mesenchymal stem cells
Yu L, et al.
BioMed Research International, 2016 (2016)
Molecular Lesions of Insulator CTCF and Its Paralogue CTCFL (BORIS) in Cancer: An Analysis from Published Genomic Studies
Voutsadakis I
High Throughput, 7(4), 30-30 (2018)
Lili Yu et al.
BioMed research international, 2016, 9872138-9872138 (2017-01-21)
Human adipose-derived mesenchymal stem cells (hAD-MSCs) are mesenchymal stem cells with the capability to modulate immune responses. Evidence showing that hAD-MSCs could mediate innate immune responses through pattern recognition receptors (PRRs) is increasing. However, the roles of PRRs in regulating
Zhiqiang Zhang et al.
Nature immunology, 14(2), 172-178 (2012-12-12)
DDX41 is a sensor of intracellular double-stranded DNA (dsDNA) in myeloid dendritic cells (mDCs) that triggers a type I interferon response via the signaling adaptor STING. We identified the E3 ligase TRIM21 as a DDX41-interacting protein and found that knockdown
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