SAB3500230
Anti-SARM antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-SARM
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), ICC, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 80 kDa
species reactivity
human, mouse
technique(s)
immunocytochemistry: suitable, indirect ELISA: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SARM1(23098)
General description
The gene SARM1 (sterile α and TIR motif containing 1) is mapped to human chromosome 17q11. It is mainly expressed in neurons. The encoded protein belongs to the MyD88 (myeloid differentiation primary response gene 88) family of adaptor proteins. The protein contains a armadillo repeat region, SAM (sterile α motif) domains and a TIR (toll-interleukin receptor) domain. It localizes in the mitochondria as well as nucleus.
Immunogen
SARM antibody was raised against a peptide corresponding to amino acids near the C-terminus of human SARM.
Biochem/physiol Actions
SARM1 (sterile α and TIR motif containing 1) is a TIR (toll-interleukin receptor) adaptor protein. It plays a crucial role in the immune system and TLR (toll like receptor) signaling. It interacts with PINK1 (PTEN-induced putative kinase 1) and is involved in the stabilization of PINK1 on depolarized mitochondria. During inflammation-mediated apoptosis, the protein is involved in the stabilization of nuclear lamins. SARM1 is also associated with Wallerian degeneration.
Features and Benefits
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Physical form
Supplied in PBS with 0.02% sodium azide.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3500230.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Xiang Zhou et al.
Developmental and comparative immunology, 39(1-2), 117-126 (2012-03-01)
Toll-like receptors (TLRs) are important pattern-recognition receptors (PRRs) that trigger innate immune response and mediate acquired immunity. Evidence has shown that SARM1 (sterile-α and TIR motif containing protein 1) is one of five TIR domain-containing adaptor proteins involved in TLRs
Chad R Sethman et al.
PloS one, 8(7), e70994-e70994 (2013-08-08)
Sterile alpha and armadillo-motif containing protein (SARM), a highly conserved and structurally unique member of the MyD88 family of Toll-like receptor adaptors, plays an important role in innate immunity signaling and apoptosis. Its exact mechanism of intracellular action remains unclear.
Laura Conforti et al.
Nature reviews. Neuroscience, 15(6), 394-409 (2014-05-21)
Axon degeneration is a prominent early feature of most neurodegenerative disorders and can also be induced directly by nerve injury in a process known as Wallerian degeneration. The discovery of genetic mutations that delay Wallerian degeneration has provided insight into
Hitoshi Murata et al.
Molecular biology of the cell, 24(18), 2772-2784 (2013-07-26)
Mutations in PTEN-induced putative kinase 1 (PINK1) or parkin cause autosomal recessive forms of Parkinson's disease. Recent work suggests that loss of mitochondrial membrane potential stabilizes PINK1 and that accumulated PINK1 recruits parkin from the cytoplasm to mitochondria for elimination
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