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Merck
CN

SML2392

DREADD Agonist 21 dihydrochloride

≥98% (HPLC), powder, DREADD agonist

Synonym(s):

11-(1-piperazinyl)-5H-Dibenzo[b,e][1,4]diazepine dihydrochloride, 11-(Piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine; 11-Piperazinyldibenzo[b,e][1,4]diazepine dihydrochloride, Compound 21 dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H18N4 · 2HCl
CAS Number:
56296-18-5
Molecular Weight:
351.27
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD25121806

Key Documents

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Product Name

DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)

InChI

1S/C17H18N4/c1-2-6-14-13(5-1)17(21-11-9-18-10-12-21)20-16-8-4-3-7-15(16)19-14/h1-8,18-19H,9-12H2

InChI key

JCBYXNSOLUVGTF-UHFFFAOYSA-N

SMILES string

C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

yellow to brown

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

Related Categories

Biochem/physiol Actions

Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).
Potent designer drug with selective agonist activity for human M3Dq (hM3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs).

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000467098
0000467098
0000415314
0000415314
0000399394

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Xin Chen et al.
ACS chemical neuroscience, 6(3), 476-484 (2015-01-15)
Over the past decade, two independent technologies have emerged and been widely adopted by the neuroscience community for remotely controlling neuronal activity: optogenetics which utilize engineered channelrhodopsin and other opsins, and chemogenetics which utilize engineered G protein-coupled receptors (Designer Receptors
Moawiah M Naffaa et al.
Cell reports, 42(7), 112783-112783 (2023-07-09)
Neurogenesis and differentiation of neural stem cells (NSCs) are controlled by cell-intrinsic molecular pathways that interact with extrinsic signaling cues. In this study, we identify a circuit that regulates neurogenesis and cell proliferation in the lateral ventricle-subventricular zone (LV-SVZ). Our
Takaki Yahiro et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 43(28), 5221-5240 (2023-06-21)
Thermoregulatory behavior in homeothermic animals is an innate behavior to defend body core temperature from environmental thermal challenges in coordination with autonomous thermoregulatory responses. In contrast to the progress in understanding the central mechanisms of autonomous thermoregulation, those of behavioral
Yoshiko Nakamura et al.
Science advances, 8(51), eadd5463-eadd5463 (2022-12-24)
The bidirectional controller of the thermoregulatory center in the preoptic area (POA) is unknown. Using rats, here, we identify prostaglandin EP3 receptor-expressing POA neurons (POAEP3R neurons) as a pivotal bidirectional controller in the central thermoregulatory mechanism. POAEP3R neurons are activated

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