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About This Item
经验公式（希尔记法）:
C17H18N4 · 2HCl
CAS Number:
分子量:
351.27
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
Product Name
DREADD Agonist 21 dihydrochloride, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
yellow to brown
溶解性
H2O: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
C1(C=CC=C2)=C2C(N3CCNCC3)=NC(C=CC=C4)=C4N1
InChI
1S/C17H18N4/c1-2-6-14-13(5-1)17(21-11-9-18-10-12-21)20-16-8-4-3-7-15(16)19-14/h1-8,18-19H,9-12H2
InChI key
JCBYXNSOLUVGTF-UHFFFAOYSA-N
相关类别
生化/生理作用
Compound 21 is a potent designer drug with full agonist activity toward human hM3Dq (EC50 = 1.7 nM by cell-based Ca2+ mobilization assay), a human M3 muscarinic receptor (M3R)-based Gq (M3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs), displaying little activity toward muscarinic acetylcholine receptor M3 (30% M3 activation at 10 μM) and reduced affinity toward H1, 5HT2A, 5HT2C, α1A receptor (fold selectivity = 3.5, 40, 100, 165, respectively). Note: the DREADD hM3Dq exhibits M3 biological activity, but is insensitive to the endogenous ligand acetylcholine (ACh).
Potent designer drug with selective agonist activity for human M3Dq (hM3Dq) DREADD (Designer Receptors Exclusively Activated by Designer Drugs).
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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