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Life science-leading tools and reagents for target and lead discovery, and preclinical screening

TARGET, LEAD, AND SAFETY SCREENING ESSENTIALS FOR DRUG DEVELOPMENT

Your critical drug discovery work may be in a CRO, pharmaceutical, or biotech lab that screens for drug targets, therapeutic leads, ADME/toxicity screening for small molecule therapeutics, and/or immune responses to biotherapeutics.  No matter where your screening process takes place, your team requires reagents of consistently high quality for drug discovery that is truly predictive of clinical efficacy and safety. 

Our solutions for scalable-throughput screening encompass:

  • Biologically-relevant, customizable assays amenable to automation
  • Reagents that enhance throughput by enabling miniaturization of assays
  • Reagent and consumable lot reservation, with a broad catalog that streamlines procurement
  • Documentation that addresses C of O, Synthetic vs. Animal Origin, Original Manufacture to enable supplier qualification
  • Bulk capabilities in support of process management during scaleup/expansion
  • Attentive customer support, with transparent communication regarding lead times
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Target Discovery

Target Discovery

Identify novel therapeutic targets using the most complete set of genome-wide functional genomics screening tools available. Our custom 10x Genomics compatible lentiviral libraries enable CRISPR screens at single-cell resolution. Validate targets using our comprehensive set of precision CRISPR and gene editing tools and uncompromising RNAi products for potent, targeted modulation of gene expression.

Lead Discovery

Our comprehensive range of disease-relevant cell lines enables tissue-specific models for drug screening. When enhanced biological relevance is needed, we’ll support your transition to high-throughput 3D cell culture models. Our organoid portfolio includes both iPSC- and patient-derived organoids, enabling drug screening with models that mimic the in vivo environment.

Gene editing is a powerful tool for achieving genome modification through knockout and knockin approaches for disease modeling.

Diverse cell analysis tools enable relevant assessment via methods like live cell imaging, with applications in cell trafficking, cell health, gene expression analysis, and cell migration. Browse reagents for live cell imaging , as well as reagents to support common cell-based assays.

High-Throughput Screening Libraries

Whether you’re looking for an off-the-shelf screening library or generating your own, we have high-throughput screening solutions to meet your requirements.

Our DNA encoded libraries enable the simultaneous interrogation of large numbers of compounds, screened in an essentially target-independent binding assay.

Streamline the process of searching, procuring, and formatting your compounds with our exceptional expertise and offering of dependable Aldrich Market Select products and services.

Accelerate pathway discovery from weeks to minutes with our SYNTHIA™ retrosynthesis software.

Preclinical Safety Testing

Screening small molecule drug candidates for safety requires assessment of drug metabolism, drug-drug interactions, and ADME/toxicity evaluation. Measuring permeability of small molecule drugs was revolutionized with the high-throughput PAMPA assay. Find a selection of plates and membranes designed for PAMPA screening.

Our CompoZr® Zinc Finger Nuclease (ZFN)-mediated knockout Caco-2 cell lines enable assessment of drug transport by comparison between the wild-type (WT) and knockout cell lines. Our iPSC-derived colon organoids provide a highly relevant model for assessment of potential compound cytotoxicity. Differentiated HepaRG cells retain major functional activities critical for drug metabolism, reactive metabolite formation, drug clearance, and CYP assays.

Assess biotherapeutic immunogenicity using our high-throughput multiplexed immunoassays, like the MILLIPLEX® Panel A that simultaneously analyzes up to 48 cytokines, chemokines, and growth factors. The potency of biologics can be diminished by development of anti-drug antibodies (ADA). The SMC™ Immunogenicity bead-based assay development kit includes all you need to develop and validate an ADA assay.

The SMC™ technology can also be used to assess PK of biotherapeutics, especially for studies of micro-dosing and understanding the full clearance of drugs at low concentrations.

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Related Applications
Gene Expression & Silencing
CRISPR, miRNA, siRNA, and shRNA technologies for gene expression and gene silencing applications.
Functional Genomics Screening
Principles of functional genomics screening in the identification of target genes through phenotypic analysis to elucidate cellular pathways and disease states and facilitate drug target identification. Includes discussion of the use of RNAi and CRISPR/Cas9 libraries for high-throughput analysis.
Cell-Based Assays
Cellular assays, or cell-based assays, are essential tools for measuring cell health, viability, proliferation, migration, invasion, chemotaxis, apoptosis, angiogenesis, oxidative stress, cell signaling and live cell analysis.
3D Cell Culture
Applications, principles, and techniques for three-dimensional (3D) cell culture. Includes techniques and descriptions of scaffold and scaffold-free methods matrices for the culture of complex in vitro models including organoids and spheroids.
Imaging Analysis & Live Cell Imaging
An overview of current tools and reagents for live cell imaging and analysis with applications in cell trafficking, cell health, gene expression analysis, cell migration, 3D cell culture, cytoskeletal dynamics and more.
Lead Discovery
Lead discovery or lead identification for drug discovery utilizes screening methods, such as high throughput screening (HTS) or DNA Encoded Library (DEL) screening, to identify lead compounds.
Synthetic Methods
Explore our building blocks for cross-coupling, fluorination, metathesis, C-H functionalization, and photocatalysis for a complete organic reaction toolbox for small molecule synthesis methods.
Related Services
Small Molecule Library Design (Aldrich Market Select)
Streamline the management of your screening compounds with our Aldrich Market Select online order center for small molecule libraries, comprising over 14 million chemistry building blocks and other useful services.
Genomic DNA Prep & Deconvolution Services
Need help with deconvolution of pooled shRNA samples after screening is complete? We provide a pooled shRNA deconvolution service that will help you identify TRC clones that are of significance in your screen.
Related Product Categories
MultiScreen® Filter Plates
MultiScreen® filtration plates in 96-well and 384-well formats with a variety of membrane options are for high throughput screening, ELISpot assays, ligand binding assays, cell-based assays, ADME testing, PCR cleanup, and sample prep.
Millicell® Cell Culture Inserts & Plates
Millicell® cell culture inserts and plates, chamber slides, and multilayer cell culture flasks are engineered for efficient cell culture, in vivo-like cell growth, and biologically relevant results. Choose hanging or standing inserts for your culture application.
Chemical Synthesis
Browse our selection of synthetic chemistry products, including coupling, halogenation, Grignard, oxidation, protection, deprotection, reduction, organoaluminium, and organosilicon reagents.
Single Molecule Counting Technology
Originally developed by Singulex®, Inc., Single Molecule Counting (SMC®) technology precisely quantifies molecules at previously undetectable levels.
RNAi Libraries
Human and mouse lentivirus shRNA screening libraries and pools from the RNAi Consortium (TRC). Available as bacterial glycerol stocks, plasmid DNA or read-to-use lentiviral particles. MISSION® RNAi libraries are also available with a range of custom vectors, volumes, and viral titers.
CRISPR & Gene Editing
Easy online ordering of predesigned or custom CRISPR guides guaranteed to produce a gene knockout at an industry leading price. Plasmid and SygRNA® synthetic formats are available to complement our extensive portfolio of Cas9 proteins, plasmids and lentivirus
Organoids
Organoids are in vitro models that closely replicate the complex physiology of native tissues while also being accessible, reproducible, and scalable like traditional culture methods. Choose colon organoids, lung organoid culture systems, and patient-derived organoids from our biobank.
Genetic Screening
We have the most comprehensive selection of screening tools in pooled and arrayed CRISPR, RNAi, and ORF formats. Whole-genome and custom designed libraries in arrayed or pooled formats meet all of your functional genomics screening needs at any scale.
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