Merck
CN

KCNJ1

potassium inwardly-rectifying channel, subfamily J, member 1

Synonyms:
KIR1.1, ROMK, ROMK1
Species:
UniProtKB ID:
Gene ID:
  • Human(3758) Summary: Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(56379) potassium inwardly-rectifying channel, subfamily J, member 1
  • Rat(24521) potassium inwardly-rectifying channel, subfamily J, member 1
  • chicken(428236) potassium inwardly-rectifying channel, subfamily J, member 1
  • Horse(100072580) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic cat(101091140) potassium inwardly-rectifying channel, subfamily J, member 1
  • cow(539250) potassium inwardly-rectifying channel, subfamily J, member 1
  • dog(489285) potassium inwardly-rectifying channel, subfamily J, member 1
  • naked mole-rat(101720253) potassium inwardly-rectifying channel, subfamily J, member 1
  • domestic guinea pig(100722828) potassium inwardly-rectifying channel, subfamily J, member 1

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Small Molecule - Activator

Product Number
Description
Species
Diazoxide, ,
Species
rat, mouse, human

Small Molecule - Antagonist

Product Number
Description
Species
Glyburide, meets USP testing specifications,
Species
rat, human
Cromakalim, ,
Species
rat
Glybenclamide, ≥99% (HPLC),
Species
rat, human
Chlorpropamide, analytical standard, ≥97%,
Species
human, mouse
Pinacidil monohydrate, powder,
Species
mouse, rat, human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-KCNJ1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-KCNJ1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
dog, guinea pig, horse, human, rabbit, rat
Application
western blot
Anti-ROMK antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
Anti-KCNJ1 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
ELISA
western blot

Small Molecule - Blocker

Product Number
Description
Species
Gliclazide, powder, ≥98%,
Species
human
Glimepiride, ≥98% (HPLC), solid,
Species
human
Repaglinide, ≥98% (HPLC), solid,
Species
human
Glipizide, solid,
Species
human
Glyburide, meets USP testing specifications,
Species
rat, human

Small Molecule - Inhibitor

Product Number
Description
Species
VU591, ≥98% (HPLC),
Species
human
Tertiapin-Q trifluoroacetate salt, ≥97% (HPLC),
Species
rat, human, mouse
Chlorpropamide, analytical standard, ≥97%,
Species
human, mouse
Pinacidil monohydrate, powder,
Species
mouse, rat, human
Tolbutamide, analytical standard,
Species
human, mouse

Small Molecule - Ligand

Product Number
Description
Species
Glimepiride, ≥98% (HPLC), solid,
Species
human
Glipizide, solid,
Species
human
Glybenclamide, ≥99% (HPLC),
Species
rat, human
Chlorpropamide, analytical standard, ≥97%,
Species
human, mouse

Small Molecule - Opener

Product Number
Description
Species
Minoxidil, ≥99% (TLC),
Species
human
Pinacidil monohydrate, powder,
Species
mouse, rat, human
Diazoxide, ,
Species
rat, mouse, human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human KCNJ1,
Species
human