ADC development
Antibody-Drug Conjugates (ADCs) are an advanced class of targeted cancer therapeutics that combine the selectivity of monoclonal antibodies with the activity of cytotoxic drugs. By delivering cytotoxic payloads directly to tumor-associated antigens, ADCs improve treatment specificity and reduce systemic toxicity compared to conventional chemotherapy. This targeted approach has contributed to the growing adoption of ADCs across oncology research and development.
The development of ADCs requires careful selection of high-quality chemicals and reagents across each stage of the workflow. Biochemical purity, formulation grade, and reagent compatibility directly determine conjugation efficiency, ADC stability, pharmacokinetic behavior, and therapeutic outcome. Their suitability and compatibility are critical for maintaining linker-payload stability, supporting reproducible ADC performance, and ensuring reliable product quality during development and manufacturing. Careful reagent selection also helps streamline development, support stringent regulatory requirements, and facilitate the advancement of ADC candidates from discovery through production.
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High-purity biochemicals enable rigorous antigen validation, antibody characterization, and early-stage screening, the quality decisions that define a successful ADC candidate.
Pharmaceutical-grade biochemicals enable site-selective conjugation, reproducible DAR control, and formulation stability to consistently yield well-characterized ADC candidates.
High-purity biochemicals support antigen validation, antibody characterization, and early screening, helping define and advance successful ADC candidates.
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Related Resources
- White paper: Establishing commercial manufacturing services for antibody-drug conjugates
This whitepaper, discusses how a CDMO leverages 15+ years experience to establish commercial-scale ADC manufacturing capabilities.
- White paper: The Evolution of antibody-drug manufacturing
Explore how ADC manufacturing has evolved and how CDMOs are adapting to meet customer needs.
- Article: Application of process analytical technology (PAT) in ADC bioconjugation process
ADC payload intermediates such as, DOLCore™, MAYCore™, and PBDCore™, simplify payload synthesis for the most commonly used payloads: maytansine, dolastatin, and PBD dimers.
- Article: What is an antibody-drug conjugate?
What antibody drug conjugates are, how bioconjugates work, design considerations and ADC services for ADC manufacturing, including bioconjugation.