Antigen Discovery Products

Identification of a specific target antigen is a crucial step in mRNA vaccine development. We offer tools for genomics analysis, protein analysis, and antibody screening techniques to provide a comprehensive approach to antigen discovery.

Pathogen and Target Antigen Identification

Understanding your pathogen at the genomic and transcriptomic level is critical for selecting the right target antigen.

Key Tools for Pathogen Analysis

SeqPlex™-I Whole Genome and Whole Transcriptome Amplification Kits

Amplify viral or pathogen genomes and transcriptomes using SeqPlex™-I Whole Genome Amplification (WGA) and Whole Transcriptome Amplification (WTA) Kits for preparation in next-generation sequencing (NGS) workflows. These kits ensure robust coverage and high-quality sequencing data, providing the foundation for identifying target antigens.

MULTI-seq High-Throughput scRNA-seq Technology for Immune Response Mapping

Multiplexing single-cell analysis, particularly single-cell RNA sequencing (scRNA-seq), is a transformative tool for studying pathogens and their interactions with host cells. By enabling the simultaneous profiling of multiple samples or experimental conditions, multiplexing enhances the efficiency, scale, and depth of pathogen analysis.

Advantages of MULTI-seq technology:

• Increased Throughput: Pooling samples reduces the number of experiments required, conserving resources.
• Reduced Batch Effects: Shared processing of multiple samples minimizes technical variability.
• Cost Efficiency: By pooling, researchers can analyze more samples per sequencing run, reducing overall costs.

Once antigens are identified, their immunogenic potential must be confirmed through comprehensive testing.

Validation Tools and Reagents

Comprehensive Recombinant Protein Expression Systems

Express candidate antigens in bacterial, yeast, insect, mammalian, or cell-free systems, each providing flexibility and optimized protein production.

Antibodies for Protein Characterization

Detect, analyze, and validate protein-protein interactions with high quality antibodies to ensure antigen functionality.

Western Blotting

Screen and identify antigen candidates efficiently using our Electrophoresis and Western blotting reagents to prioritize those most likely to elicit an immune response.

ELISA

Screen antigens for immunogenicity and assess antibody binding potential with reliable tools including ELISA-validated antibodies, ELISA kits, and MultiScreen^® ELISA high-binding plates.

mRNA Design and Optimization

Engineer your validated antigen into a translatable mRNA construct for vaccine development with innovative solutions for mRNA expression.

Simplicon™ In Vivo Protein Expression System

Our Simplicon™ In Vivo Protein Expression System is a novel, self-replicative RNA-based system for immediate and sustained protein expression into transiently transfected human cells. Ideal for validating antigen constructs in a natural cellular environment.

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