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Merck
CN

103241

4-Methoxy-1-naphthaldehyde

99%

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About This Item

Linear Formula:
CH3OC10H6CHO
CAS Number:
Molecular Weight:
186.21
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
240-109-2
MDL number:
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Product Name

4-Methoxy-1-naphthaldehyde, 99%

InChI key

MVXMNHYVCLMLDD-UHFFFAOYSA-N

InChI

1S/C12H10O2/c1-14-12-7-6-9(8-13)10-4-2-3-5-11(10)12/h2-8H,1H3

SMILES string

COc1ccc(C=O)c2ccccc12

assay

99%

form

solid

bp

212 °C/40 mmHg (lit.)

mp

35-36 °C (lit.)

Quality Level

Application

4-Methoxy-1-naphthaldehyde was used in fluorometric enzymatic assay for determination of activity of class I and II alcohol dehydrogenase isoenzymes in human pancreas and in human liver homogenates.

Biochem/physiol Actions

4-Methoxy-1-naphthaldehyde is fluorogenic substrate for human alcohol dehydrogenase (ADH).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Jayaraman Jayabharathi et al.
Journal of fluorescence, 26(1), 307-316 (2015-11-21)
Efficient hole transport materials based on novel fused methoxynaphthyl phenanthrimidazole core structure were synthesised and characterized. Their device performances in phosphorescent organic light emitting diodes were investigated. The high thermal stability in combination with the reversible oxidation process made promising
Lech Chrostek et al.
Journal of clinical laboratory analysis, 17(3), 93-96 (2003-04-16)
Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), which are most abundant in the liver, are the main enzymes involved in ethanol metabolism in humans. Gender-related differences in total liver ADH and ALDH activity among different animal species have been observed
L Chrostek et al.
Clinical chemistry and laboratory medicine, 38(5), 409-412 (2000-08-22)
We have measured the activity of class I and II alcohol dehydrogenase isoenzymes in the sera of patients with liver tumours, using class-specific fluorogenic naphthaldehydes as substrates. The activity of the tested isoenzymes was unchanged in primary tumours and significantly
Lech Chrostek et al.
Digestive diseases and sciences, 48(7), 1230-1233 (2003-07-23)
Ethanol metabolism in the pancreas occurs predominantly by way of an nonoxidative pathway to fatty acid ethyl esters but oxidative routes to acetaldehyde also may contribute to injury of pancreatic cells. Three metabolic systems are responsible for the oxidative metabolism
J Wierzchowski et al.
Analytical chemistry, 64(2), 181-186 (1992-01-15)
Both class I and class II alcohol dehydrogenase (ADH) activities are present in human serum. The contribution of each class can be measured using two class-specific, fluorogenic substrates, 4-methoxy-1-naphthaldehyde and 6-methoxy-2-naphthaldehyde. The former is highly selective for class I isozymes

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