106615
2,2-Bis(hydroxymethyl)propionic acid
98%
Synonym(s):
Bis-MPA, DMPA®, Dimethylolpropionic acid
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About This Item
Linear Formula:
(HOCH2)2C(CH3)COOH
CAS Number:
Molecular Weight:
134.13
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
225-306-3
Beilstein/REAXYS Number:
1756385
MDL number:
Assay:
98%
Form:
solid
vapor density
<1 (vs air)
Quality Level
assay
98%
form
solid
mp
189-191 °C (lit.)
solubility
H2O: soluble, acetone: slightly soluble, benzene: insoluble, methanol: soluble
functional group
carboxylic acid, hydroxyl
SMILES string
CC(CO)(CO)C(O)=O
InChI
1S/C5H10O4/c1-5(2-6,3-7)4(8)9/h6-7H,2-3H2,1H3,(H,8,9)
InChI key
PTBDIHRZYDMNKB-UHFFFAOYSA-N
Application
2,2-Bis(hydroxymethyl)propionic acid based fourth generation tridendron dendrimer having 48 hydroxyl groups was synthesized.
2,2-Bis(hydroxymethyl)propionic acid is commonly used as an AB2 monomer for the synthesis of hyperbranched (hb) polymers and dendrimers.
2,2-Bis(hydroxymethyl)propionic acid was used in the synthesis and characterization studies of polyurethane dispersion modified with polymethylsiloxane (Si-PUD) and its nanocomposites incorporated with clays.2,2-Bis(hydroxymethyl)propionic acid based dendrimers have potent applications as delivery systems for potent anticancer drugs such as cisplatin and doxorubicin, as well as agents for both boron neutron capture therapy and photodynamic therapy.
Simple derivatives of this acid have been used to construct dendritic architectures via the "click" azide-acetylene cycloaddition.
Legal Information
DMPA is a registered trademark of GEO Specialty Chemicals, Inc.
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Kazuki Fukushima et al.
Biomaterials science, 7(6), 2288-2296 (2019-04-25)
Cationic aliphatic polycarbonates bearing primary ammonium side chains have been developed with relatively high molecular weights and controlled macromolecular architectures. These polycarbonates exhibit reasonable antimicrobial activity against Gram-negative and Gram-positive bacteria. The prepared homopolymers could be effective against Gram-negative bacteria
First divergent strategy using two AB2 unprotected monomers for the rapid synthesis of dendrimers.
Brauge L, et al.
Journal of the American Chemical Society, 123(27), 6698-6699 (2001)
Elizabeth R Gillies et al.
Drug discovery today, 10(1), 35-43 (2005-01-29)
The unique properties of dendrimers, such as their high degree of branching, multivalency, globular architecture and well-defined molecular weight, make them promising new scaffolds for drug delivery. In the past decade, research has increased on the design and synthesis of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 106615-100G | 04061838674272 |
| 106615-3KG | 04061838674296 |
| 106615-500G | 04061838674302 |
| 106615-12KG | 04061838674289 |