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108073

8-Hydroxyquinoline hemisulfate salt hemihydrate

Name: 8-Hydroxyquinoline hemisulfate salt hemihydrate
Brand: ALDRICH

98%

Synonym(s):

8-Quinolinol hemisulfate, 8-Quinolinol sulfate (2:1) monohydrate

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About This Item

Empirical Formula (Hill Notation):

C₉H₇NO · 0.5H₂O₄S · 0.5H₂O

CAS Number:

207386-91-2

Molecular Weight:

203.20

NACRES:

NA.22

PubChem Substance ID:

24846798

UNSPSC Code:

12352100

EC Number:

205-137-1

MDL number:

MFCD00149610

Assay:

98%

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Properties

Quality Level

200

assay

98%

mp

176-179 °C (lit.)

solubility

H₂O: soluble 100 mg/mL, clear to slightly hazy, yellow to orange

SMILES string

[H]O[H].OS(O)(=O)=O.Oc1cccc2cccnc12.Oc3cccc4cccnc34

InChI

1S/2C9H7NO.H2O4S.H2O/c2*11-8-5-1-3-7-4-2-6-10-9(7)8;1-5(2,3)4;/h2*1-6,11H;(H2,1,2,3,4);1H2

InChI key

BNCXJZDIJIVJJO-UHFFFAOYSA-N

Description

Biochem/physiol Actions

It is a potential copper ligand and is a tested effective proteasome inhibitor.

Preparation Note

8-Hydroxyquinoline hemisulfate salt hemihydrate dissolves in water at a concentration of 100 mg/ml to form a clear to slightly hazy, yellow to yellow-orange coloured solution.

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells.

Kenyon G Daniel et al.

Biochemical pharmacology, 67(6), 1139-1151 (2004-03-10)

Here we report that organic copper complexes can potently and selectively inhibit the chymotrypsin-like activity of the proteasome in vitro and in vivo. Several copper compounds, such as NCI-109268 and bis-8-hydroxyquinoline copper(II) [Cu(8-OHQ)(2)], can inhibit the chymotrypsin-like activity of purified

Global Trade Item Number

SKU	GTIN
108073-100G	04061838677952