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Merck
CN

120618

4-Hydroxypyridine

95%

Synonym(s):

4-Pyridinol, 4-Pyridone

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About This Item

Empirical Formula (Hill Notation):
C5H5NO
CAS Number:
Molecular Weight:
95.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-958-3
Beilstein/REAXYS Number:
105800
MDL number:
Assay:
95%
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InChI key

GCNTZFIIOFTKIY-UHFFFAOYSA-N

InChI

1S/C5H5NO/c7-5-1-3-6-4-2-5/h1-4H,(H,6,7)

SMILES string

O=C1C=CNC=C1

assay

95%

bp

230-235 °C/12 mmHg (lit.)

mp

150-151 °C (lit.)

Quality Level

Application

4-Hydroxypyridine was used in the synthesis of (Ag3MoO3F3) (Ag3MoO4)Cl by hydro(solvato)thermal methods. It was used as model compound to study the natural photodegradation of representative aquatic environmental contaminants.

pictograms

CorrosionExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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G P Carlson
Toxicology letters, 85(3), 173-178 (1996-06-01)
In order to evaluate the possibility that the metabolism of pyridine may be important for its toxic actions, pyridine was compared with pyridine N-oxide, 2-hydroxypyridine, 3-hydroxypyridine, 4-hydroxypyridine and pyridinium methyliodide in rats given equal molar doses of the chemicals i.p.
Fazlul Huq et al.
Medicinal chemistry (Shariqah (United Arab Emirates)), 5(4), 372-381 (2009-08-20)
This paper describes the synthesis, characterization, cytotoxicity of a new trinuclear Pt-Pd-Pt complex code named TH8 containing two 4-hydroxypyridine ligands bound to the central metal ion. In addition to its activity against human ovarian cancer cell lines: A2780, A2780(cisR) and
Tilman Lechel et al.
The Journal of organic chemistry, 75(3), 726-732 (2009-12-25)
A three-component reaction with lithiated alkoxyallenes, nitriles, and perfluorinated carboxylic acids as precursors led to a series of perfluoroalkyl- or perfluoroaryl-substituted 4-hydroxypyridine derivatives. These compounds were converted into 4-pyridyl nonaflates which can be employed as versatile building blocks for the
M M Iba et al.
Archives of biochemistry and biophysics, 378(2), 299-310 (2000-06-22)
We compared pyridine and five of its metabolites in terms of (i) in vivo induction of CYP1A1 expression in the lung, kidney, and liver in the rat and (ii) in vitro binding to, and activation of, the aryl hydrocarbon receptor
A new and flexible synthesis of 4-hydroxypyridines: rapid access to caerulomycins A, E and functionalized terpyridines.
Jyotirmayee Dash et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 15(28), 6811-6814 (2009-06-18)

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