122912
2-Amino-6,8-dihydroxypurine
Synonym(s):
2-Amino-6,8-purinediol, 8-Hydroxyguanine
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About This Item
Empirical Formula (Hill Notation):
C5H5N5O2
CAS Number:
Molecular Weight:
167.13
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
227-035-6
MDL number:
InChI key
CLGFIVUFZRGQRP-UHFFFAOYSA-N
InChI
1S/C5H5N5O2/c6-4-8-2-1(3(11)10-4)7-5(12)9-2/h(H5,6,7,8,9,10,11,12)
SMILES string
Nc1nc(O)c2[nH]c(O)nc2n1
impurities
<10% acetic acid
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
235.4 °F - closed cup
flash_point_c
113 °C - closed cup
Regulatory Information
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Jia Guo et al.
Nucleic acids research, 41(16), 7700-7712 (2013-06-19)
Oxidized bases in DNA have been implicated in cancer, aging and neurodegenerative disease. We have developed an approach combining single-cell gel electrophoresis (comet) with fluorescence in situ hybridization (FISH) that enables the comparative quantification of low, physiologically relevant levels of
Ilinca Nicolae et al.
Experimental and therapeutic medicine, 17(2), 1012-1019 (2019-01-27)
Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted
Ana-Maria Chiorcea-Paquim et al.
Mikrochimica acta, 188(2), 58-58 (2021-01-29)
Oxidative DNA damage plays an important role in the pathogenesis of various diseases. Among oxidative DNA lesions, 8-oxoguanine (8-oxoG) and its corresponding nucleotide 8-oxo-2'-deoxyguanosine (8-oxodG), the guanine and deoxyguanosine oxidation products, have gained much attention, being considered biomarkers for oxidative
Eleonora Parlanti et al.
Free radical biology & medicine, 53(11), 2171-2177 (2012-09-27)
Although oxidatively damaged DNA is repaired primarily via the base excision repair (BER) pathway, it is now evident that multiple subpathways are needed. Yet, their relative contributions and coordination are still unclear. Here, mouse embryo fibroblasts (MEFs) from selected nucleotide
Sara Timpano et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(4), 5716-5728 (2019-01-17)
Multicellular organisms balance oxygen delivery and toxicity by having oxygen pass through several barriers before cellular delivery. In human cell culture, these physiologic barriers are removed, exposing cells to higher oxygen levels. Human cells cultured in ambient air may appear
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