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123323

Quinazoline

Name: Quinazoline
Brand: ALDRICH

99%

Synonym(s):

1,3-Benzodiazine, Benzopyrimidine

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About This Item

Empirical Formula (Hill Notation):

C₈H₆N₂

CAS Number:

253-82-7

Molecular Weight:

130.15

EC Number:

205-965-3

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24847559

Beilstein/REAXYS Number:

109370

MDL number:

MFCD00006712

Assay:

99%

Form:

solid

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Properties

Quality Level

100

assay

99%

form

solid

bp

243 °C (lit.)

mp

46-48 °C (lit.)

solubility

H₂O: freely soluble, organic solvents: soluble

SMILES string

c1ccc2ncncc2c1

InChI

1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H

InChI key

JWVCLYRUEFBMGU-UHFFFAOYSA-N

Description

General description

Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.

Application

Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.

Biochem/physiol Actions

Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).

Storage Class

11 - Combustible Solids

flash_point_f

222.8 °F - closed cup

flash_point_c

106 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)

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Polarographic and voltammetric determination of quinazoline-the structural unit of anticancer drugs.

Hladikova J, et al.

Sensing in Electroanalysis, 3, 165-175 (2008)

Presence of pyrroloquinazoline alkaloid in Adhatoda vasica attenuates inflammatory response through the downregulation of pro-inflammatory mediators in LPS stimulated RAW 264.7 macrophages.

Reddy Amala et al.

BioImpacts : BI, 11(1), 15-22 (2021-01-21)

Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue. A signaling cascade of growth factors and

The Valuable Impacts of Halophytic Genus Suaeda; Nutritional, Chemical, and Biological Values.

Hamdoon A Mohammed

Medicinal chemistry (Shariqah (United Arab Emirates)), 16(8), 1044-1057 (2020-02-25)

Suaeda is a halophytic genus belonging to the Amaranthaceae family and can survive in the high salted marsh areas of the world. Suaeda plants can biosynthesize natural substances with powerful antioxidant activity and are considered as a renewable source of

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Global Trade Item Number

SKU	GTIN
123323-1G	04061838722249
123323-5G	04061833544372