123323
Quinazoline
99%
Synonym(s):
1,3-Benzodiazine, Benzopyrimidine
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About This Item
Empirical Formula (Hill Notation):
C8H6N2
CAS Number:
Molecular Weight:
130.15
EC Number:
205-965-3
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
Beilstein/REAXYS Number:
109370
MDL number:
Assay:
99%
Form:
solid
InChI key
JWVCLYRUEFBMGU-UHFFFAOYSA-N
InChI
1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H
SMILES string
c1ccc2ncncc2c1
assay
99%
form
solid
bp
243 °C (lit.)
Quality Level
solubility
H2O: freely soluble, organic solvents: soluble
Related Categories
General description
Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
Application
Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.
Biochem/physiol Actions
Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).
Storage Class
11 - Combustible Solids
flash_point_f
222.8 °F - closed cup
flash_point_c
106 °C - closed cup
ppe
Eyeshields, Gloves, type N95 (US)
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Polarographic and voltammetric determination of quinazoline-the structural unit of anticancer drugs.
Hladikova J, et al.
Sensing in Electroanalysis, 3, 165-175 (2008)
Elham Bagheri et al.
Current pharmaceutical design, 24(13), 1395-1404 (2018-02-01)
Quinazoline is an aromatic bicyclic compound exhibiting several pharmaceutical and biological activities. This study was conducted to investigate the potential wound healing properties of Synthetic Quinazoline Compound (SQC) on experimental rats. The toxicity of SQC was determined by MTT cell
Kunal Nepali et al.
European journal of medicinal chemistry, 196, 112291-112291 (2020-04-24)
This study reports the design, synthesis and evaluation of a series of histone deacetylase (HDAC) inhibitors containing purine/purine isoster as a capping group and an N-(2-aminophenyl)-benzamide unit. In vitro cytotoxicity studies reveal that benzamide 14 suppressed the growth of triple-negative breast
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