125504
Cyclopropylamine
98%
Synonym(s):
Aminocyclopropane
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About This Item
Linear Formula:
C3H5NH2
CAS Number:
Molecular Weight:
57.09
Beilstein:
741858
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
vapor pressure
4.67 psi ( 20 °C)
Quality Level
Assay
98%
form
liquid
autoignition temp.
527 °F
refractive index
n20/D 1.420 (lit.)
bp
49-50 °C (lit.)
density
0.824 g/mL at 25 °C (lit.)
SMILES string
NC1CC1
InChI
1S/C3H7N/c4-3-1-2-3/h3H,1-2,4H2
InChI key
HTJDQJBWANPRPF-UHFFFAOYSA-N
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Application
Cyclopropylamine(CPA) has been used in the synthesis of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It has been used in the synthesis of Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.
Biochem/physiol Actions
Cyclopropylamine inactivates cytochrome P450 enzymes by a mechanism involving initial one-electron oxidation at nitrogen followed by scission of the cyclopropane ring leading to covalent modification of the enzyme. It is a mechanism-based inhibitor of quinoprotein methylamine dehydrogenase from Paracoccus denitrificans.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Flam. Liq. 2 - Skin Corr. 1B
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point(F)
33.8 °F - closed cup
Flash Point(C)
1 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
危险化学品
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Dapeng Sun et al.
FEBS letters, 517(1-3), 172-174 (2002-06-14)
Cyclopropylamine is a mechanism-based inhibitor of the quinoprotein methylamine dehydrogenase (MADH) from Paracoccus denitrificans. The resulting inactivation is accompanied by the formation of a covalent cross-link between the alpha and beta subunits of MADH. The results of site-directed mutagenesis studies
Synthesis and Antifungal Activity of 5-[2-(Alkylamino) pyrimidin-4-yl]-4-phenylthiazol-2-cycloalkylamine Derivatives on Phytophthora capsici.
Nam Sw, et al.
J. Korean Chem. Soc., 54(3), 395-402 (2011)
Intermolecular [3+2] cycloaddition of cyclopropylamines with olefins by visible-light photocatalysis.
Soumitra Maity et al.
Angewandte Chemie (International ed. in English), 51(1), 222-226 (2011-11-24)
Ana Paula B Vintém et al.
Bioorganic & medicinal chemistry, 13(10), 3487-3495 (2005-04-26)
Modification of cysteine (Cys) residues inactivates monoamine oxidases (MAO) yet the crystal structure shows no conserved cysteines in the active site of MAO A (Ma, J. et al. J. Mol. Biol.2004, 338, 103-114). MAO A cysteine 374 was mutated to
Etienne Veignie et al.
Environmental pollution (Barking, Essex : 1987), 129(1), 1-4 (2004-01-30)
In order to study the enzymatic mechanisms involved in the successive steps of BaP degradation by a Deuteromycete fungus Fusarium solani, we developed an indirect approach by using inhibitors of enzymes. We used either specific inhibitors of peroxidases (i.e. salicylhydroxamic
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