126136
Diethyl methylmalonate
99%
Synonym(s):
Methylmalonic acid diethyl ester
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About This Item
Linear Formula:
CH3CH(COOC2H5)2
CAS Number:
Molecular Weight:
174.19
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-175-7
Beilstein/REAXYS Number:
637028
MDL number:
Assay:
99%
Product Name
Diethyl methylmalonate, 99%
InChI key
UPQZOUHVTJNGFK-UHFFFAOYSA-N
InChI
1S/C8H14O4/c1-4-11-7(9)6(3)8(10)12-5-2/h6H,4-5H2,1-3H3
SMILES string
CCOC(=O)C(C)C(=O)OCC
assay
99%
refractive index
n20/D 1.413 (lit.)
bp
198-199 °C (lit.)
78-80 °C/10 mmHg
density
1.022 g/mL at 20 °C (lit.)
Quality Level
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Application
Diethyl methylmalonate was used to investigate the effect of direct supplementation of the medium with di-ester of methylmalonate on erythromycin fermentation in Saccharopolyspora erythraea mutB strain.
General description
Diethyl methylmalonate reacts with 2-cyclohexenone under abnormal Michael conditions form 2-(3-oxocyclohexyl)-2-cyclohexenone. It causes the alkylation of poly(chloromethylstyrene) during pahse transfer catalysis.
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
179.6 °F - closed cup
flash_point_c
82 °C - closed cup
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Alkylation reaction of poly (chloromethylstyrene) with malononitrile and diethyl methylmalonate using phase transfer catalysts.
Nishikubo T, et al.
Makromol. Chem., 2(6-7), 387-392 (1981)
J Mark Weber et al.
Applied microbiology and biotechnology, 93(4), 1575-1583 (2011-11-04)
The Saccharopolyspora erythraea mutB knockout strain, FL2281, having a block in the methylmalonyl-CoA mutase reaction, was found to carry a diethyl methylmalonate-responsive (Dmr) phenotype in an oil-based fermentation medium. The Dmr phenotype confers the ability to increase erythromycin A (erythromycin)
Abnormal Michael reaction. Reaction between 2-cyclohexenone and diethyl methylmalonate.
Risinger GE and Haag WG.
The Journal of Organic Chemistry, 38(20), 3546-3647 (1973)
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