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Merck
CN

128201

N-Ethyl-o-crotonotoluidide

97%

Synonym(s):

N-Ethyl-N-(2-methylphenyl)-2-butenamide, Crotamiton

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About This Item

Linear Formula:
CH3CH=CHCON(C2H5)C6H4CH3
CAS Number:
483-63-6
Molecular Weight:
203.28
NACRES:
NA.22
PubChem Substance ID:
24847834
UNSPSC Code:
12352100
EC Number:
207-596-3
MDL number:
MFCD00026989

Key Documents

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Product Name

N-Ethyl-o-crotonotoluidide, 97%

InChI key

DNTGGZPQPQTDQF-XBXARRHUSA-N

InChI

1S/C13H17NO/c1-4-8-13(15)14(5-2)12-10-7-6-9-11(12)3/h4,6-10H,5H2,1-3H3/b8-4+

SMILES string

CCN(C(=O)\C=C\C)c1ccccc1C

description

predominantly trans

assay

97%

form

solid

refractive index

n20/D 1.54 (lit.)

bp

153-155 °C/13 mmHg (lit.)

solubility

ethanol: soluble
methanol: soluble

density

0.987 g/mL at 25 °C (lit.)

Quality Level

100

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Application

N-Ethyl-o-crotonotoluidide ( Crotamiton) was used to study the photocatalytic decomposition of crotamiton in aqueous solution using TiO2.
N-Ethyl-o-crotonotoluidide (Crotamiton) was used to treat scabies and various pruritic dermatoses.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
12204EU
10402BN
06028AW
04727CZ
35705DN

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The use of N-ethyl-o-crotonotoluidide in the treatment of scabies and various pruritic dermatoses.
M COUPERUS
The Journal of investigative dermatology, 13(1), 35-42 (1949-07-01)
Allergic contact dermatitis due to crotamiton.
H Hara et al.
Contact dermatitis, 49(4), 219-219 (2004-03-05)
Kyoung-Jin Kim et al.
Pediatric dermatology, 19(5), 409-411 (2002-10-18)
Misdiagnosis is frequent in scabies of infants and children because of a low index of suspicion, secondary eczematous changes, and inappropriate therapy. Topical or systemic corticosteroids may modify the clinical presentation of scabies and that situation is referred to as
Demodecidosis manifested on the external genitalia.
S M Hwang et al.
International journal of dermatology, 37(8), 634-636 (1998-09-10)
Ulrich R Hengge et al.
The Lancet. Infectious diseases, 6(12), 769-779 (2006-11-25)
Scabies has been a scourge among human beings for thousands of years. Its worldwide occurrence with epidemics during war, famine, and overcrowding is responsible for an estimated 300 million people currently infested. Scabies refers to the various skin lesions produced
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