128430
L-Glutamic acid
99%
Synonym(s):
(S)-2-Aminopentanedioic acid, Glu
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About This Item
Linear Formula:
HO2CCH2CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
147.13
EC Number:
200-293-7
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
1723801
assay
99%
optical activity
[α]20/D +31.5°, c = 2 in 5 M HCl
mp
205 °C (dec.) (lit.)
solubility
H2O: soluble 140 gm/l at 100 degrees c, H2O: soluble 21.86 gm/l at 50 degrees c, H2O: soluble 55.32 gm/l at 75 degrees c, H2O: soluble 8.64 gm/l at 25 degrees c, hydrochloric acid: soluble 10% in 1 N, clear, colorless
SMILES string
N[C@@H](CCC(O)=O)C(O)=O
InChI
1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChI key
WHUUTDBJXJRKMK-VKHMYHEASA-N
Application
L-Glutamic acid has been used as a supplement for selection medium, SORB-TOP-His.
Biochem/physiol Actions
An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
L-Glutamic acid along with l-Lysine is used for preparation of Bifunctional DTPA-like Ligands. L-glutamic acid can stimulate the spontaneous release of [3H] dopamine ( [3H] DA).
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Storage Class
11 - Combustible Solids
wgk
WGK 1
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices.
M F Giorguieff et al.
Neuroscience letters, 6(1), 73-77 (1977-10-01)
Kimberly J Dougherty et al.
Neuron, 80(4), 920-933 (2013-11-26)
Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilaterally
Nils Muhlert et al.
Journal of neurology, neurosurgery, and psychiatry, 85(8), 833-839 (2014-01-17)
Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive impairment is common in multiple sclerosis (MS), and understanding its mechanisms is crucial for developing effective treatments. We used structural and metabolic brain imaging to test