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Merck
CN

128430

L-Glutamic acid

99%

Synonym(s):

(S)-2-Aminopentanedioic acid, Glu

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About This Item

Linear Formula:
HO2CCH2CH2CH(NH2)CO2H
CAS Number:
56-86-0
Molecular Weight:
147.13
EC Number:
200-293-7
UNSPSC Code:
12352209
MDL number:
MFCD00002634
Beilstein/REAXYS Number:
1723801

Key Documents

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InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChI key

WHUUTDBJXJRKMK-VKHMYHEASA-N

SMILES string

N[C@@H](CCC(O)=O)C(O)=O

assay

99%

optical activity

[α]20/D +31.5°, c = 2 in 5 M HCl

mp

205 °C (dec.) (lit.)

solubility

H2O: soluble 140 gm/l at 100 degrees c, H2O: soluble 21.86 gm/l at 50 degrees c, H2O: soluble 55.32 gm/l at 75 degrees c, H2O: soluble 8.64 gm/l at 25 degrees c, hydrochloric acid: soluble 10% in 1 N, clear, colorless

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Application

L-Glutamic acid has been used as a supplement for selection medium, SORB-TOP-His.

Biochem/physiol Actions

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).
L-Glutamic acid along with l-Lysine is used for preparation of Bifunctional DTPA-like Ligands. L-glutamic acid can stimulate the spontaneous release of [3H] dopamine ( [3H] DA).

Storage Class

11 - Combustible Solids

wgk

WGK 1

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
S47160
S45561
00607PH
00807PH
09421KH

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Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices.
M F Giorguieff et al.
Neuroscience letters, 6(1), 73-77 (1977-10-01)
Kimberly J Dougherty et al.
Neuron, 80(4), 920-933 (2013-11-26)
Locomotion is controlled by spinal networks that generate rhythm and coordinate left-right and flexor-extensor patterning. Defined populations of spinal interneurons have been linked to patterning circuits; however, neurons comprising the rhythm-generating kernel have remained elusive. Here, we identify an ipsilaterally
Ulrike Pannasch et al.
Nature neuroscience, 17(4), 549-558 (2014-03-04)
Astrocytes play active roles in brain physiology by dynamic interactions with neurons. Connexin 30, one of the two main astroglial gap-junction subunits, is thought to be involved in behavioral and basic cognitive processes. However, the underlying cellular and molecular mechanisms
Marijke De Bock et al.
Biochimica et biophysica acta, 1843(10), 2211-2232 (2014-04-29)
For decades, studies have been focusing on the neuronal abnormalities that accompany neurodegenerative disorders. Yet, glial cells are emerging as important players in numerous neurological diseases. Astrocytes, the main type of glia in the central nervous system , form extensive
Nils Muhlert et al.
Journal of neurology, neurosurgery, and psychiatry, 85(8), 833-839 (2014-01-17)
Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive impairment is common in multiple sclerosis (MS), and understanding its mechanisms is crucial for developing effective treatments. We used structural and metabolic brain imaging to test
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