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130222

5-Nitroisoquinoline

Name: 5-Nitroisoquinoline
Brand: ALDRICH

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About This Item

Empirical Formula (Hill Notation):

C₉H₆N₂O₂

CAS Number:

607-32-9

Molecular Weight:

174.16

NACRES:

NA.22

PubChem Substance ID:

24847952

UNSPSC Code:

12352100

EC Number:

210-133-8

MDL number:

MFCD00006905

Assay:

98%

Form:

powder

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Properties

Quality Level

100

assay

98%

form

powder

mp

106-109 °C (lit.)

SMILES string

[O-][N+](=O)c1cccc2cnccc12

InChI

1S/C9H6N2O2/c12-11(13)9-3-1-2-7-6-10-5-4-8(7)9/h1-6H

InChI key

PYGMPFQCCWBTJQ-UHFFFAOYSA-N

Description

General description

5-Nitroisoquinoline reacted with vinylmagnesium bromide to form a number of pyrroloisoquinolines. 5-Nitroisoquinoline derivatives (potential antimalarial drugs) were evaluated for mutagenic (MUT) and chromosome-damaging (CHR) activities by the Salmonella test.

Application

5-Nitroisoquinoline was used to prepare a number of pyrroloisoquinolines.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Implication of nitro group reduction in the mutagenic and chromosome damaging activities of 22 new 5-nitroisoquinolines by the Salmonella mutagenicity test and the cytokinesis-blocked micronucleus assay.

T Orsière et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 41(2), 275-290 (2002-12-14)

The mutagenic (MUT) and chromosome-damaging (CHR) activities of 22 potential antimalarial drugs (5-nitroisoquinoline derivatives) were evaluated by the Salmonella test and the cytokinesis-blocked micronucleus assay (CBMN). The Salmonella mutagenicity test was performed with and without metabolic activation (S9 mix) in

An expeditious synthesis of cytotoxic pyrroloisoquinoline derivatives. Structure-activity comparative studies with isomeric pyrroloquinolines.

Margarita Vlachou et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 17(3), 139-143 (2002-10-24)

A number of pyrroloisoquinolines have been prepared by reaction of 5-nitroisoquinoline with vinylmagnesium bromide followed by N-alkylation with the appropriate 2-chloro-N,N-dialkylethylamine. Their cytotoxicity was evaluated in a number of ovarian cell lines and compared to their analogous isomeric pyrroloquinolines. Two

Effects of hydrogen bonding on the gas-phase reactivity of didehydroisoquinolinium cation isomers.

Nelson R Vinueza et al.

Physical chemistry chemical physics : PCCP, 20(33), 21567-21572 (2018-08-11)

Two previously unreported isomeric biradicals with a 1,4-radical topology, the 1,5-didehydroisoquinolinium cation and the 4,8-didehydroisoquinolinium cation, and an additional, previously reported isomer, the 4,5-didehydroisoquinolinium cation, were studied to examine the importance of the exact location of the radical sites on

Global Trade Item Number

SKU	GTIN
130222-5G	04061838727336