130710
4-Chloro-DL-phenylalanine
99%
Synonym(s):
PCP, PCPA
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About This Item
Linear Formula:
ClC6H4CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
199.63
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
231-051-9
MDL number:
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
assay
99%
mp
>240 °C (dec.) (lit.)
Biochem/physiol Actions
Tryptophan hydroxylase inhibitor.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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E Manová et al.
The British journal of dermatology, 171(6), 1368-1374 (2014-08-27)
Octocrylene (OCT) is an ultraviolet (UV) filter used in personal care products (PCPs) to prevent sun-related skin damage. OCT is photostable and has the ability to photostabilize other UV filters, which has recently led to its increased use in PCPs.
Silvina L Diaz et al.
The European journal of neuroscience, 38(5), 2650-2658 (2013-07-12)
Increased adult neurogenesis is a major neurobiological correlate of the beneficial effects of antidepressants. Indeed, selective serotonin (5-HT) re-uptake inhibitors, which increase 5-HT transmission, enhance adult neurogenesis in the dentate gyrus (DG) of the hippocampus. However, the consequences of 5-HT
Ana C Stein et al.
Behavioural brain research, 228(1), 66-73 (2011-12-14)
In this study we have demonstrated that cyclohexane extract of Hypericum polyanthemum (POL) and its main phloroglucinol derivative uliginosin B (ULI) present antidepressant-like activity in rodent forced swimming test (FST). The involvement of monoaminergic neurotransmission on the antidepressant-like activity of
Ryan J McLaughlin et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 22(9), 664-671 (2012-02-14)
The endocannabinoid system has recently emerged as a vital component of the stress response and is an appealing target for the treatment of mood and anxiety disorders. Additionally, corticolimbic endocannabinoid signaling is important for stress-induced regulation of emotional behavior. However
Matilda Bäckberg et al.
Clinical toxicology (Philadelphia, Pa.), 53(9), 856-864 (2015-08-22)
3-Methoxy-phencyclidine (3-MeO-PCP) and 4-methoxy-phencyclidine (4-MeO-PCP) are analogs of and drug substitutes for the dissociative substance PCP ("Angel dust"), a recreational drug that was most popular in the 1970s. In Sweden, use of methoxylated PCP analogs was noted starting in mid-2013
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