130710
4-Chloro-DL-phenylalanine
99%
Synonym(s):
PCP, PCPA
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About This Item
Linear Formula:
ClC6H4CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
199.63
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
231-051-9
MDL number:
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
assay
99%
mp
>240 °C (dec.) (lit.)
Biochem/physiol Actions
Tryptophan hydroxylase inhibitor.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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E Manová et al.
The British journal of dermatology, 171(6), 1368-1374 (2014-08-27)
Octocrylene (OCT) is an ultraviolet (UV) filter used in personal care products (PCPs) to prevent sun-related skin damage. OCT is photostable and has the ability to photostabilize other UV filters, which has recently led to its increased use in PCPs.
Matilda Bäckberg et al.
Clinical toxicology (Philadelphia, Pa.), 53(9), 856-864 (2015-08-22)
3-Methoxy-phencyclidine (3-MeO-PCP) and 4-methoxy-phencyclidine (4-MeO-PCP) are analogs of and drug substitutes for the dissociative substance PCP ("Angel dust"), a recreational drug that was most popular in the 1970s. In Sweden, use of methoxylated PCP analogs was noted starting in mid-2013
Mark J Airhart et al.
Neurotoxicology and teratology, 34(1), 152-160 (2011-09-07)
In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM
Alicia Izquierdo et al.
Behavioural brain research, 233(2), 494-499 (2012-06-02)
Aside from the well-known influence of serotonin (5-hydroxytryptamine, 5-HT) on emotional regulation, more recent investigations have revealed the importance of this monoamine in modulating cognition. Parachlorophenylalanine (PCPA) depletes 5-HT by inhibiting tryptophan hydroxylase, the enzyme required for 5-HT synthesis and
Shannon M Steinberg et al.
Cancer immunology research, 2(11), 1044-1050 (2014-09-04)
A growing body of evidence suggests that BRAF inhibitors, in addition to their acute tumor growth-inhibitory effects, can also promote immune responses to melanoma. The present study aimed to define the immunologic basis of BRAF-inhibitor therapy using the Braf/Pten model
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