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132888

2-Chloro-4′-fluoroacetophenone

99%

Synonym(s):

ω-Chloro-4-fluoroacetophenone, 4-Fluorophenacyl chloride

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About This Item

Linear Formula:
FC6H4COCH2Cl
CAS Number:
456-04-2
Molecular Weight:
172.58
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24848083
EC Number:
207-256-4
Beilstein/REAXYS Number:
637860
MDL number:
MFCD00011652
Assay:
99%
Form:
solid
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assay

99%

form

solid

mp

47-50 °C (lit.)

functional group

chloro, fluoro, ketone

SMILES string

Fc1ccc(cc1)C(=O)CCl

InChI

1S/C8H6ClFO/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2

InChI key

UJZWJOQRSMOFMA-UHFFFAOYSA-N

Gene Information

human ... PTPN6(5777)

General description

2-Chloro-4′-fluoroacetophenone on condensation with N-methyl-4-(methylthio)benzamidine yields 1-methyl-2-(4-methylthio)phenyl-4-(4-fluoro)phenylimidazole.

Application

2-Chloro-4′-fluoroacetophenone was used in the synthesis of S-(phenacyl)glutathiones and 2-[3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-(4-fluorophenyl)ethanone.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

230.0 °F - closed cup

flash_point_c

110 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCJ2814
MKBL2871V
MKBH6083V
MKBF6666
MKBC1660

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Allergic contact dermatitis from 3-(alpha-methoxy) methylenebenzofuran-2(3H)-one (MBF) and alpha-chloro-4-fluoroacetophenone (CFAP) in chemical process workers.
M J Boffa et al.
Contact dermatitis, 34(6), 434-435 (1996-06-01)
Donald M N Sikazwe et al.
Bioorganic & medicinal chemistry, 17(4), 1716-1723 (2009-01-22)
Arylcycloalkylamines, such as phenyl piperidines and piperazines and their arylalkyl substituents, constitute pharmacophoric groups exemplified in several antipsychotic agents. A review of previous reports indicates that arylalkyl substituents can improve the potency and selectivity of the binding affinity at D(2)-like
Philip G Board et al.
Chemical research in toxicology, 20(1), 149-154 (2007-01-18)
S-(Phenacyl)glutathione reductase (SPG-R) plays a significant role in the biotransformation of reactive alpha-haloketones to nontoxic acetophenones. Comparison of the apparent subunit size, amino acid composition, and catalysis of the reduction of S-(phenacyl)glutathiones indicated that a previously described rat SPG-R (Kitada
View All Related Papers

Global Trade Item Number

SKUGTIN
132888-100G04061831828252
132888-25G04061831828269