135933
5-Chloro-2-hydroxypyridine
97%
Synonym(s):
5-Chloro-2-pyridinol
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About This Item
Empirical Formula (Hill Notation):
C5H4ClNO
CAS Number:
Molecular Weight:
129.54
UNSPSC Code:
12352100
PubChem Substance ID:
EC Number:
224-146-1
MDL number:
Assay:
97%
InChI key
SZFUWUOHDRMCKD-UHFFFAOYSA-N
InChI
1S/C5H4ClNO/c6-4-1-2-5(8)7-3-4/h1-3H,(H,7,8)
SMILES string
Oc1ccc(Cl)cn1
assay
97%
mp
163-165 °C (lit.)
functional group
chloro
Application
5-chloro-2-hydroxypyridine (5-Chloro-2-pyridinol) was used to study the effect of dicumarol on xanthine dehydrogenase and mechanism of mitomycin C bioreduction by xanthine dehydrogenase.
General description
5-chloro-2-hydroxypyridine acts as donor ligand and exists in zwitterionic form, i.e. 5-chloropyridinium-2-olate in copper complexes.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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D L Gustafson et al.
Cancer research, 52(24), 6936-6939 (1992-12-15)
These studies examined the effect of dicumarol on xanthine dehydrogenase (XDH), an enzyme recently shown to bioreduce mitomycin C. Dicumarol, which has previously been shown to inhibit xanthine oxidase (XO), inhibited both XDH and XO mediated conversion of xanthine to
D L Gustafson et al.
Cancer research, 53(22), 5470-5474 (1993-11-15)
These studies examined the kinetic and mechanistic parameters of mitomycin C (MMC) bioreduction by xanthine dehydrogenase (XDH), an enzyme recently shown to be capable of MMC activation. The bioreduction of MMC by XDH leads to the formation of 2,7-diaminomitosene (2,7-DM)
Ji-Xin Yuan et al.
Acta crystallographica. Section C, Crystal structure communications, 58(Pt 4), M270-M272 (2002-04-05)
In the title compound, [Cu(C(5)H(4)ClNO)(2)(C(4)H(4)N(2))(H(2)O)(2)](ClO(4))(2), the Cu atom, which lies on an inversion centre, has an octahedral environment. The pyrazine ligand also lies about an inversion centre and links adjacent Cu atoms into a chain running along the b axis;
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