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Merck
CN

137111

Ethoxyacetic acid

98%

Synonym(s):

O-Ethylglycolic acid

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About This Item

Linear Formula:
C2H5OCH2COOH
CAS Number:
Molecular Weight:
104.10
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
210-978-2
Beilstein/REAXYS Number:
1743037
MDL number:
Assay:
98%
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assay

98%

refractive index

n20/D 1.419 (lit.)

bp

97-100 °C/11 mmHg (lit.)

density

1.102 g/mL at 25 °C (lit.)

functional group

carboxylic acid, ether

SMILES string

CCOCC(O)=O

InChI

1S/C4H8O3/c1-2-7-3-4(5)6/h2-3H2,1H3,(H,5,6)

InChI key

YZGQDNOIGFBYKF-UHFFFAOYSA-N

General description

Ethoxyacetic acid is biomarker of exposure to widely used industrial chemicals such as alkyl-substituted ethylene glycols and other aliphatic ethers.

Application

Ethoxyacetic acid is metabolite of glycol ether alkoxy acid and was used to evaluate its toxicity in embryonic stem cell test in mouse. It was used in zebrafish embryotoxicity test to study chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis in ovo.

Biochem/physiol Actions

Ethoxyacetic acid induces testicular toxicity in rats in vivo .


pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 3

flash_point_f

206.6 °F - closed cup

flash_point_c

97 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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L Aasmoe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 27(12), 1237-1244 (1998-02-14)
1. The elimination of 2-methoxyethanol (2-ME) and its toxic metabolite methoxyacetic acid (MAA) was studied in the male and female rat. We also studied the elimination of ethoxyacetic acid (EAA), the toxic metabolite formed by 2-ethoxyethanol (2-EE). 2. The rate
J C Hoflack et al.
Mutation research, 341(4), 281-287 (1995-02-01)
Ethylene glycol ethers, their aldehyde and their acid metabolites were evaluated for their mutagenicity with the Ames test. The Salmonella typhimurium his- tester strains TA 97a, TA 98, TA 100 and TA 102 were used with and without rat S9
T Sakai et al.
International archives of occupational and environmental health, 64(7), 495-498 (1993-01-01)
In control subjects and workers exposed to glycol ethers and their acetates, we determined the urinary metabolites (three alkoxyacetic acids) by a simple and rapid method. Levels of urinary metabolites were significantly higher in the solvent workers than in the



Global Trade Item Number

SKUGTIN
137111-25G04061836673956
137111-100G04061836682309