137111
Ethoxyacetic acid
98%
Synonym(s):
O-Ethylglycolic acid
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About This Item
Linear Formula:
C2H5OCH2COOH
CAS Number:
Molecular Weight:
104.10
Beilstein:
1743037
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Assay
98%
refractive index
n20/D 1.419 (lit.)
bp
97-100 °C/11 mmHg (lit.)
density
1.102 g/mL at 25 °C (lit.)
functional group
carboxylic acid
ether
SMILES string
CCOCC(O)=O
InChI
1S/C4H8O3/c1-2-7-3-4(5)6/h2-3H2,1H3,(H,5,6)
InChI key
YZGQDNOIGFBYKF-UHFFFAOYSA-N
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General description
Ethoxyacetic acid is biomarker of exposure to widely used industrial chemicals such as alkyl-substituted ethylene glycols and other aliphatic ethers.
Application
Ethoxyacetic acid is metabolite of glycol ether alkoxy acid and was used to evaluate its toxicity in embryonic stem cell test in mouse. It was used in zebrafish embryotoxicity test to study chemical toxicity after exposure of the complete vertebrate embryo during embryogenesis in ovo.
Biochem/physiol Actions
Ethoxyacetic acid induces testicular toxicity in rats in vivo .
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class Code
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Flash Point(F)
206.6 °F - closed cup
Flash Point(C)
97 °C - closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Esther de Jong et al.
Toxicological sciences : an official journal of the Society of Toxicology, 110(1), 117-124 (2009-04-30)
The embryonic stem cell test (EST) has been proposed as an in vitro assay that might reduce animal experimentation in regulatory developmental toxicology. So far, evaluation of the EST was not performed using compounds within distinct chemical classes. Evaluation within
J Liesivuori et al.
Archives of toxicology, 73(4-5), 229-232 (1999-08-27)
Male Wistar rats were given ethanediol (9.4 g/l), 2-ethoxyethylacetate (5.4 g/l), 2-butoxyethylacetate (2.9 g/l) and 1,2-propanediol (40 g/l) respectively in their drinking water for 2 weeks. Urine was collected during the last 24 h of the exposure. There was a
H Veulemans et al.
British journal of industrial medicine, 50(1), 71-78 (1993-01-01)
A case-control study was conducted among first time patients at a clinic for reproductive disorders. The study group consisted of 1019 cases, defined as patients diagnosed infertile or subfertile on the basis of a spermiogram and 475 controls who were
L Aasmoe et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(4), 417-424 (1999-06-22)
1. The pharmacokinetics of methoxyacetic acid (MAA) and ethoxyacetic acid (EAA) have been determined in the male and female rat following bolus intravenous administration at 100 mg/kg. The plasma-concentration data of MAA fitted well to a one-compartment model, and the
T Sakai et al.
International archives of occupational and environmental health, 64(7), 495-498 (1993-01-01)
In control subjects and workers exposed to glycol ethers and their acetates, we determined the urinary metabolites (three alkoxyacetic acids) by a simple and rapid method. Levels of urinary metabolites were significantly higher in the solvent workers than in the
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