138339
N-(2-Hydroxyethyl)phthalimide
99%
Synonym(s):
2-Phthalimidoethanol
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About This Item
Empirical Formula (Hill Notation):
C10H9NO3
CAS Number:
Molecular Weight:
191.18
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
223-434-4
Beilstein/REAXYS Number:
147214
MDL number:
Product Name
N-(2-Hydroxyethyl)phthalimide, 99%
InChI key
MWFLUYFYHANMCM-UHFFFAOYSA-N
InChI
1S/C10H9NO3/c12-6-5-11-9(13)7-3-1-2-4-8(7)10(11)14/h1-4,12H,5-6H2
SMILES string
OCCN1C(=O)c2ccccc2C1=O
assay
99%
form
solid
mp
126-128 °C (lit.)
functional group
hydroxyl
imide
Quality Level
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General description
N-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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J L Kelley et al.
Journal of medicinal chemistry, 24(12), 1528-1531 (1981-12-01)
A number of nitrogen analogues of 9-[(2-hydroxyethoxy)methyl]guanine [acylovir, Zovirax] containing amine functions in the side chain were synthesized and tested for antiviral activity. These purine acyclic nucleosides were prepared by reaction of tris(trimethylsilyl)guanine or 2,6-diaminopurine sodium salt with the chloromethyl
Molluscicidal activity of synthetic derivatives of 2-hydroxyethylphthalimide.
J N Lopes et al.
Revista brasileira de biologia, 40(3), 635-637 (1980-08-01)
Xuanrong Guo et al.
Biomacromolecules, 20(9), 3464-3474 (2019-07-25)
We report the design of reactive and hydrolytically degradable multilayers by the covalent layer-by-layer assembly of an azlactone-containing polymer, poly(2-vinyl-4,4-dimethylazlactone), with an acid-degradable, acetal-containing, small-molecule diamine linker. This approach yields cross-linked multilayers that contain (i) residual azlactone reactivity that can
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