139491
Methylglyoxal bis(guanylhydrazone) dihydrochloride hydrate
99%
Synonym(s):
Methyl GAG dihydrochloride
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About This Item
Linear Formula:
CH3C[=NNHC(=NH)NH2]CH[=NNHC(=NH)NH2] · 2HCl · xH2O
CAS Number:
Molecular Weight:
257.12 (anhydrous basis)
UNSPSC Code:
12352100
PubChem Substance ID:
MDL number:
InChI
1S/C5H12N8.ClH.H2O/c1-3(11-13-5(8)9)2-10-12-4(6)7;;/h2H,1H3,(H4,6,7,12)(H4,8,9,13);1H;1H2
SMILES string
O.Cl.CC(C=NNC(N)=N)=NNC(N)=N
InChI key
DHFAMLHAUITXFU-UHFFFAOYSA-N
assay
99%
mp
255 °C (dec.) (lit.)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases.
H G Williams-Ashman et al.
Biochemical and biophysical research communications, 46(1), 288-295 (1972-01-14)
Paradoxical enhancement of S-adenosylmethionine decarboxylase in rat tissues following administration of the specific inhibitor methyl glyoxal bis(guanylhydrazone).
A E Pegg et al.
Biochemical and biophysical research communications, 52(2), 696-701 (1973-05-15)
Effects of methylglyoxal-bis(guanylhydrazone) on polyamine metabolism in spleens of mice with disseminated L1210 lymphoid leukemia.
O Heby et al.
Cancer research, 34(4), 886-892 (1974-04-01)
Polyamines and polyamine-metabolizing enzyme activities in human semen.
J Jänne et al.
Clinica chimica acta; international journal of clinical chemistry, 48(4), 393-401 (1973-11-15)
C W Porter et al.
Cancer research, 40(7), 2330-2335 (1980-07-01)
The use of methylglyoxal-bis(guanylhydrazone) (MGBG) in the clinical treatment of myeloid and lymphoid disorders has been limited by severe host toxicity to renewing tissues, particularly the intestinal mucosa. Since the drug is a potent inhibitor of spermidine biosynthesis, the distributions
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