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140325

8-Hydroxy-5-nitroquinoline

Name: 8-Hydroxy-5-nitroquinoline
Brand: ALDRICH

96%

Synonym(s):

5-Nitro-8-quinolinol

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About This Item

Empirical Formula (Hill Notation):

C₉H₆N₂O₃

CAS Number:

4008-48-4

Molecular Weight:

190.16

NACRES:

NA.22

PubChem Substance ID:

24848465

UNSPSC Code:

12352100

EC Number:

223-662-4

MDL number:

MFCD00006791

Assay:

96%

Form:

powder

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Properties

Quality Level

100

assay

96%

form

powder

mp

181-183 °C (lit.)

solubility

alcohol: very slightly soluble, diethyl ether: very slightly soluble, hydrochloric acid: freely soluble (hot)

functional group

nitro

SMILES string

Oc1ccc([N+]([O-])=O)c2cccnc12

InChI

1S/C9H6N2O3/c12-8-4-3-7(11(13)14)6-2-1-5-10-9(6)8/h1-5,12H

InChI key

RJIWZDNTCBHXAL-UHFFFAOYSA-N

Description

Application

8-Hydroxy-5-nitroquinoline was used in the synthesis of novel CO₂-soluble 8-hydroxyquinoline chelating agents.

Biochem/physiol Actions

8-Hydroxy-5-nitroquinoline is an effective anti-microbial and anti-cancer agent. It is an effective drug for the treatment of urinary tract infections due to gram negative bacilli.

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331,H315,H319,H335

pcodes

P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Highly CO₂-soluble 5-Amido-8-hydroxyquinoline Chelating Agents for Extraction of Metals in Sc-CO₂.

Chang F, et al.

Bull. Korean Chem. Soc., 29(7), 1327-1327 (2008)

Effects of repurposed drug candidates nitroxoline and nelfinavir as single agents or in combination with erlotinib in pancreatic cancer cells.

Serena Veschi et al.

Journal of experimental & clinical cancer research : CR, 37(1), 236-236 (2018-09-23)

Pancreatic cancer (PC) is the fourth most common cause of cancer death. Combination therapies with classical chemotherapeutic agents improved treatment of advanced PC at the cost of a relevant toxicity, but the 5-year survival rate remains below 5%. Consequently, new

Electrochemistry of the antibacterial and antifungal drug nitroxoline and its determination in bulk form, pharmaceutical formulation and human blood.

Mohamed M Ghoneim et al.

Bioelectrochemistry (Amsterdam, Netherlands), 80(2), 162-168 (2010-09-14)

Nitroxoline has been reduced at the mercury electrode in buffered solutions (pH 2-11) in two irreversible cathodic steps. The first step was attributed to reduction of -NO(2) group to the hydroxylamine stage and the second one to reduction-saturation of the

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Global Trade Item Number

SKU	GTIN
140325-5G	04061838733382