14075
Succinic semialdehyde solution
~15% in H2O (T)
Synonym(s):
4-Oxobutanoic acid, 4-Oxobutyric acid, Succinaldehydic acid, Succinic semialdehyde monomer
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About This Item
Linear Formula:
HCOCH2CH2COOH
CAS Number:
Molecular Weight:
102.09
PubChem Substance ID:
UNSPSC Code:
12352100
MDL number:
Beilstein/REAXYS Number:
1745187
SMILES string
OC(=O)CCC=O
concentration
~15% in H2O (T)
storage temp.
2-8°C
Other Notes
Enzyme-catalyzed aldol reaction with DHAP; Substrate for succinic semialdehyde dehydrogenase
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
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Baiqiang Yuan et al.
Journal of nutritional science and vitaminology, 54(3), 185-190 (2008-07-19)
We have found for the first time that a chromosomal gene, mlr6787, in Mesorhizobium loti encodes the pyridoxine degradative enzyme alpha-(N-acetylaminomethylene)succinic acid (AAMS) amidohydrolase. The recombinant enzyme expressed in Escherichia coli cells was homogeneously purified and characterized. The enzyme consisted
W.-D. Fessner et al.
Angewandte Chemie (International Edition in English), 103, 596-596 (1991)
Kathryn M McCulloch et al.
Biochemistry, 49(6), 1226-1235 (2010-01-27)
The gene identification and kinetic characterization of (E)-2-(acetamidomethylene)succinate (E-2AMS) hydrolase has recently been described. This enzyme catalyzes the final reaction in the degradation of vitamin B(6) and produces succinic semialdehyde, acetate, ammonia, and carbon dioxide from E-2AMS. The structure of
Luiz Pedro S de Carvalho et al.
Archives of biochemistry and biophysics, 509(1), 90-99 (2011-02-10)
Succinic semialdehyde dehydrogenases (SSADHs) are ubiquitous enzymes that catalyze the NAD(P)+-coupled oxidation of succinic semialdehyde (SSA) to succinate, the last step of the γ-aminobutyrate shunt. Mycobacterium tuberculosis encodes two paralogous SSADHs (gabD1 and gabD2). Here, we describe the first mechanistic
Hatice Gökcan et al.
The Journal of organic chemistry, 77(13), 5533-5543 (2012-06-01)
Pyridoxal 5-phosphate (PLP), the phosphorylated and the oxidized form of vitamin B6 is an organic cofactor. PLP forms a Schiff base with the ϵ-amino group of a lysine residue of PLP-dependent enzymes. γ-Aminobutyric acid (GABA) aminotransferase is a PLP-dependent enzyme
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