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141186

Chloromethyl pivalate

97%

Synonym(s):

POM-Cl, Pivaloyloxymethyl chloride

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About This Item

Linear Formula:
(CH3)3CCOOCH2Cl
CAS Number:
18997-19-8
Molecular Weight:
150.60
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
24848492
EC Number:
242-735-1
Beilstein/REAXYS Number:
1560838
MDL number:
MFCD00000884
Assay:
97%
Form:
liquid
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Quality Segment

200

assay

97%

form

liquid

reaction suitability

reactivity: phosphate reactive, reactivity: phosphonate reactive, reagent type: protection reagent, reactivity: carboxyl reactive

refractive index

n20/D 1.417 (lit.)

bp

146-148 °C (lit.)

density

1.045 g/mL at 25 °C (lit.)

functional group

chloro, ester

SMILES string

CC(C)(C)C(=O)OCCl

InChI

1S/C6H11ClO2/c1-6(2,3)5(8)9-4-7/h4H2,1-3H3

InChI key

GGRHYQCXXYLUTL-UHFFFAOYSA-N

General description

Chloromethyl pivalate reacts with sodium salt of sulbactam to yield sulbactam pivoxil. It undergoes acylation reaction with 9-(2-phosphonylmethoxyethyl)adenine (PMEA) to yield bis(pivaloyloxymethyl) PMEA.

Application

Chloromethyl pivalate was used in the synthesis of pivaloyloxy methyl ester of ofloxacin as prodrug. It was used as the reagent during the synthesis of an isoindoline-annulated, tricyclic sultam library via microwave-assisted, continuous-flow organic synthesis.

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

104.0 °F - closed cup

flash_point_c

40 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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