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About This Item
Linear Formula:
ClCOOCH2CCl3
CAS Number:
Molecular Weight:
211.86
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
241-363-7
Beilstein/REAXYS Number:
970619
MDL number:
Assay:
98%
Form:
liquid
vapor pressure
0.06 psi ( 20 °C)
Quality Level
assay
98%
form
liquid
refractive index
n20/D 1.471 (lit.)
bp
171-172 °C (lit.)
density
1.539 g/mL at 25 °C (lit.)
functional group
chloro
storage temp.
2-8°C
SMILES string
ClC(=O)OCC(Cl)(Cl)Cl
InChI
1S/C3H2Cl4O2/c4-2(8)9-1-3(5,6)7/h1H2
InChI key
LJCZNYWLQZZIOS-UHFFFAOYSA-N
General description
2,2,2-Trichloroethyl chloroformate (TrocCl) serves as a versatile reagent used for selective acylation and dealkylation in organic synthesis. It is used in regio, chemo, and stereoselective synthesis.
Application
- 2,2,2-Trichloroethyl chloroformate was used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples.
- It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.
- It was used as reagent during N-demethylation of dextromethorphan.
- It was used as protecting reagent for aliphatic and aromatic hydroxyl and amino groups.
Protecting reagent for aliphatic and aromatic hydroxyl and amino groups.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Inhalation - Eye Dam. 1 - Skin Corr. 1B
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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A M Crider et al.
Journal of pharmaceutical sciences, 70(12), 1319-1321 (1981-12-01)
6-Nor-9,10-dihydrolysergic acid methyl ester (IV) was prepared by demethylation of 9,10-dihydrolysergic acid methyl ester (II) with 2,2,2-trichloroethyl chloroformate, followed by reduction of the intermediate carbamate (III) with zinc in acetic acid. The 6-ethyl-V and 6-n-propyl-VI derivatives were prepared by alkylation
A Dasgupta et al.
American journal of clinical pathology, 109(5), 527-532 (1998-05-12)
Amphetamine and methamphetamine are commonly abused central nervous system stimulants. We describe a rapid new derivatization of amphetamine and methamphetamine using 2,2,2-trichloroethyl chloroformate for gas chromatography-mass spectrometric analysis. Amphetamine and methamphetamine, along with N-propyl amphetamine (internal standard), were extracted from
2, 2, 2-Trichloroethyl Chloroformate (TrocCl)
EO dos Reis, et al.
Synlett, 2007, 1473-1474 (2007)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 142077-25G | 04061838734211 |
| 142077-100G | 04061836691127 |

