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142077

2,2,2-Trichloroethyl chloroformate

Name: 2,2,2-Trichloroethyl chloroformate
Brand: ALDRICH

98%

Synonym(s):

2,2,2-Trichloroethoxycarbonyl chloride

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About This Item

Linear Formula:

ClCOOCH₂CCl₃

CAS Number:

17341-93-4

Molecular Weight:

211.86

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24848380

EC Number:

241-363-7

Beilstein/REAXYS Number:

970619

MDL number:

MFCD00000810

Assay:

98%

Form:

liquid

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Properties

vapor pressure

0.06 psi ( 20 °C)

Quality Level

200

assay

98%

form

liquid

refractive index

n20/D 1.471 (lit.)

bp

171-172 °C (lit.)

density

1.539 g/mL at 25 °C (lit.)

functional group

chloro

storage temp.

2-8°C

SMILES string

ClC(=O)OCC(Cl)(Cl)Cl

InChI

1S/C3H2Cl4O2/c4-2(8)9-1-3(5,6)7/h1H2

InChI key

LJCZNYWLQZZIOS-UHFFFAOYSA-N

Description

General description

2,2,2-Trichloroethyl chloroformate (TrocCl) serves as a versatile reagent used for selective acylation and dealkylation in organic synthesis. It is used in regio, chemo, and stereoselective synthesis.

Application

2,2,2-Trichloroethyl chloroformate was used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples.
It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester.
It was used as reagent during N-demethylation of dextromethorphan.
It was used as protecting reagent for aliphatic and aromatic hydroxyl and amino groups.

Protecting reagent for aliphatic and aromatic hydroxyl and amino groups.

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pictograms

GHS06,GHS05

signalword

Danger

hcodes

H314,H331

pcodes

P280 - P303 + P361 + P353 - P304 + P340 + P311 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 3 Inhalation - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Gas chromatography/mass spectrometry determination of amphetamine-related drugs and ephedrines in plasma, urine and hair samples after derivatization with 2,2,2-trichloroethyl chloroformate.

Giampietro Frison et al.

Rapid communications in mass spectrometry : RCM, 19(7), 919-927 (2005-03-05)

A new analytical approach, based on derivatization with 2,2,2-trichloroethyl chloroformate and gas chromatography/mass spectrometry (GC/MS), was investigated for qualitative and quantitative analyses of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples. Sample preparation involved

Gas chromatography/mass spectrometry determination of mephedrone in drug seizures after derivatization with 2,2,2-trichloroethyl chloroformate.